摘要
瑞马唑仑是一种新型的超短效苯二氮[艹卓]类镇静药,与咪达唑仑相比,瑞马唑仑起效迅速,恢复时间短,且长时间输注后不会出现蓄积,其作用同样可以被氟马西尼拮抗;与丙泊酚相比,瑞马唑仑不易引起心血管抑制、呼吸抑制和注射痛。瑞马唑仑在内镜诊疗操作方面的镇静作用不劣于丙泊酚和咪达唑仑。本研究针对瑞马唑仑的作用机制、药代动力学特点及其在老年患者的最新应用研究进行阐述,旨在为临床提供理论依据。
Remimazolam is a new ultra-short-acting benzodiazepine sedative.Compared with midazolam,remimazolam has rapid onset,short recovery time,and no accumulation after long-term infusion.Its effect can also be antagonized by flumazenil.Compared with propofol,remimazolam is not easy to cause cardiovascular depression,respiratory depression and injection pain.The sedative effect of remimazolam is not inferior to that of propofol and midazolam in endoscopic diagnosis and treatment.This study describes the mechanism of action,pharmacokinetic characteristics and the latest research in elderly patients of remimazolam in order to provide a theoretical basis for clinical application.
作者
姚文壮
张涵云
吕洁萍
Yao Wenzhuang;Zhang Hanyun;LüJieping(College of Anesthesiology,Shanxi Medical University,Taiyuan 030000,China;Department of Anesthesiology,First Hospital of Shanxi Medical University,Taiyuan 030000,China)
出处
《实用药物与临床》
CAS
2023年第11期1052-1056,共5页
Practical Pharmacy and Clinical Remedies
基金
山西省医师协会医师临床科研—围术期镇痛镇静项目(YSXH-RF2022MZ005)。
