摘要
目的观察四逆萸连赭石汤对胆热犯胃型胃食管反流病的临床疗效。方法选取2022年1—10月德州市中医院门诊及住院诊断为胆热犯胃型胃食管反流病患者76例,采用随机数表法分为治疗组与对照组,每组各38例。两组均给予基础治疗,治疗组加服四逆萸连赭石汤,每日1剂,对照组加服雷贝拉唑20 mg,每日1次,疗程均为8周,比较两组治疗前后中医证候积分、中医证候疗效评价、反流性疾病问卷(RDQ)评分,并随访1个月比较两组好转率、复发率以及食管黏膜炎症积分。结果治疗后,两组中医证候积分低于治疗前,且治疗组中医证候积分低于对照组,差异有统计学意义(P<0.05)。治疗组中医证候疗效高于对照组,差异有统计学意义(P<0.05)。治疗后,两组RDQ评分均低于治疗前,且治疗组RDQ评分低于对照组,差异有统计学意义(P<0.05)。随访1个月,治疗组好转率高于对照组,复发率和食管黏膜炎症积分低于对照组,差异均有统计学意义(P<0.05)。结论四逆萸连赭石汤可明显改善胆热犯胃型胃食管反流病患者的临床症状,减少复发率,增加黏膜愈合率,近远期疗效良好。
Objective To observe the clinical efficacy of Siniyulianzheshi decoction on gastroesophageal reflux disease of gallbladder heat invading stomach type.Methods From January to October 2022,a total of 76 patients with gastroesophageal reflux disease of gallbladder-heat invading stomach type diagnosed in the outpatient and inpatient departments of Dezhou Traditional Chinese Medicine Hospital were divided into the treatment group and the control group using the random number table method,with 38 cases in each group.Both groups were given basic treatment.The treatment group was given Siniyulianzheshi Decoction,one dose a day,and the control group was given rabeprazole 20 mg once a day for 8 weeks.The TCM syndrome score,TCM syndrome efficacy evaluation and reflux disease questionnaire(RDQ)score were compared before and after treatment.After a follow-up of one month,the recovery rate,recurrence rate and score of esophageal mucositis of the two groups were compared.Results After treatment,the TCM syndrome scores of both groups decreased compared to before,and the scores in the treatment group was lower than that in the control group,with a statistically significant difference(P<0.05).The therapeutic effect of traditional Chinese medicine syndrome in the treatment group was higher than that in the control group,with a statistically significant difference(P<0.05).After treatment,the RDQ score of both groups decreased compared to before,and the score in the treatment group was lower than that of the control group,with a statistically significant difference(P<0.05).After one month of treatment,the recovery rate of the treatment group were higher than those of the control group,and the recurrence rate and score of esophageal mucositis was lower than that of the control group,with statistically significant differences(P<0.05).Conclusion Siniyulianzheshi decoction can significantly improve the clinical symptoms of patients with gallbladder-heat invading stomach type gastroesophageal reflux disease,reduce the recurrence rate,incr
作者
李慧丽
李勇
牟倩
LI Huii;LI Yong;MOU Qian(Department of Spleen and Stomach Diseases,Dezhou Traditional Chinese Medicine Hospital,Shandong,Dezhou 253000,China)
出处
《中国医药科学》
2023年第22期12-16,共5页
China Medicine And Pharmacy
基金
山东省中医药科技项目(M-2022110)。
关键词
四逆萸连赭石汤
雷贝拉唑
胆热犯胃
胃食管反流病
Siniyulianzheshi Decoction
Rabeprazole
Gallbladder-heat invading stomach
Gastroesophageal reflux disease
