摘要
目的:探索不同自身抗体阳性原发性干燥综合征(pSS)患者舌象特点。方法:纳入2018年12月至2021年9月于中日友好医院中医风湿病科就诊的pSS患者,统一采集舌象和自身抗体。χ^(2)检验比较不同自身抗体阳性患者舌象特点,phi相关分析自身抗体与舌象相关性。结果:共纳入pSS患者173例,抗核抗体(ANA)滴度≥1∶160较滴度<1∶160患者存在舌体裂纹、少津,舌色红绛,剥脱苔比例更高(P<0.05,P<0.01),舌苔厚、腻比例更低(P<0.05)。抗着丝点蛋白B(CENP-B)抗体阳性较阴性患者舌体裂纹比例更高(P<0.01),舌苔厚、腻比例更低(P<0.05)。类风湿因子(RF)阳性较阴性患者舌苔燥、剥脱苔比例更高(P<0.05)。部分自身抗体与舌象间均呈弱相关(φ<0.4)。结论:ANA滴度≥1∶160、抗CENP-B抗体及RF阳性pSS患者易见气阴两虚舌象,且前两种少见痰湿舌象,可为pSS中医现代化研究提供参考。
Objective:To explore the characteristics of tongue appearances in patients with primary Sjogren's syndrome(pSS)with different positive autoantibodies.Methods:Patients with pSS who were treated in the Department of TCM Rheumatology,China-Japan Friendship Hospital,from December 2018 to September 2021 were enrolled,tongue appearances and autoantibodies were collected uniformly.Chi-square test were used to analyze the features of tongue appearances for patients with different positive autoantibodies,phi correlation analysis were used to test the correlation between autoantibodies and tongue appearances.Results:A total of 173 patients with pSS were included in this study,patients with pSS with ANA titer≥l:160 presented with cracked tongue,less fluid tongue,deep-red tongue,and a high proportion of exfoliation(P<0.05,P<0.01),a lower proportion of thick coating,and greasy coating(P<0.05);Patients with positive for anti-centromere protein B(CENP-B)antibodies had a higher proportion of cracked tongue(P<0.01),and a lower proportion of thick coating,and greasy coating(P<0.05);Patients with pSS who were positive for rheumatoid factor(RF)had a higher proportion of dry coating,and exfoliation(P<0.05).There was a weak correlation between part of autoantibodies and tongue appearances(<0.4).Conclusion:Patients with pSS with ANA titer≥1:160,positive for anti-CENP-B antibodies or positive for RF are more likely to appear a tongue appearances with qi and yin deficiency.And the first two kinds of patients are more rarely to appear tongue appearances with phlegm-damp syndrome.This study can provide reference for pSS TCM modernization research.
作者
黄子玮
吴子华
杨建英
张燕
张丽宁
胡琪
罗静
陶庆文
HUANG Ziwei;WU Zihua;YANG Jianying;ZHANG Yan;ZHANG Lining;HU Qi;LUO Jing;TAO Qingwen(Graduate School of Beijing University of Chinese Medicine,Bejing 100029,China;Department of TCM Rheumatology,China-Japan Friendship Hospital,Beijing Key Laboratory of Immune Inflammatory Disease,Beijing 100029,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2023年第11期5514-5518,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
中央高水平医院临床科研业务费资助(No.2022-NHLHCRF-LX-02-0301)
中日友好医院“菁英计划”人才培育工程(No.ZRJY2021-QM14)
首都卫生发展科研专项青年优才项目(No.2020-4-40610)。
关键词
原发性干燥综合征
舌象
自身抗体
着丝点蛋白B
类风湿因子
Primary Sjogren's syndrome(pSS)
Tongue appearances
Autoantibodies
Centromere protein B(CENP-B)
Rheumatoid factor(RF)
