摘要
原发性干燥综合征(pSS)标志性特征之一是患者血清存在多种自身抗体,包括传统自身抗体用于疾病诊断分类,还有与其他自身免疫性疾病相关的自身抗体,以及从小鼠模型中鉴定出的新型自身抗体等.自身抗体与pSS疾病诊断、预后和临床表现密切相关,抗Ro60抗体和抗Ro52抗体在阳性率和临床相关性等方面存在差异,新型抗体在pSS诊断和分型中有重要作用.这些新进展进一步提高了pSS诊断的准确性,为基础与临床研究提供借鉴和参考.
One of the hallmarks of primary Sjögren's syndrome(pSS)is the presence of various autoantibodies in patients'serum,including traditional autoantibodies for disease diagnosis and classification,autoantibodies associated with other autoimmune diseases,and the novel autoantibodies identified from mouse models.The autoantibodies are closely related to the diagnosis,prognosis,and clinical manifestations of pSS.There are significant differences in the prevalence and clinical correlations between anti-Ro60 antibody and anti-Ro52 antibody.Also,the novel autoantibodies play an important role in the diagnosis and classification of pSS.These advances further improve the accuracy of pSS diagnosis and provide references for basic and clinical research.
作者
蔡鑫
周雅馨
李红霞
吴振彪
CAI Xin;ZHOU Yaxin;LI Hongxia;WU Zhenbiao(Department of Clinical Immunology,Xijing Hospital,Air Force Medical University,Xi'an 710032,China)
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2021年第6期563-568,共6页
Chinese Journal of Cellular and Molecular Immunology
关键词
干燥综合征
自身抗体
诊断
临床表型
综述
primary Sjögren's syndrome
autoantibodies
diagnosis
clinical phenotype
review
