摘要
重症肌无力(MG)是一种主要累及神经-肌肉接头突触后膜乙酰胆碱受体的获得性自身免疫性疾病。临床上主要表现为部分或全身骨骼肌无力和极易疲劳,活动后加重,经休息和胆碱酯酶抑制剂治疗后症状减轻。大多数MG患者可见胸腺病理改变。研究表明,胸腺病毒感染及慢性炎症刺激、异常免疫激活、胸腺中枢耐受性破坏及免疫调节失衡参与了MG的发生和发展过程。
Myasthenia gravis （MG） is an acquired autoimmune disease mostly affected the postsynaptic membrane of neuro-muscular joint, namely the acetylcholine receptor. The clinical features were partially or generally skeletal muscle weakness and easy fatigue, symptoms aggravating after activities and alleviating after cholinesterase inhibitor distribution or relaxation. Thymic pathological changes were found in most MG patients. Studies have shown that viral infection and chronic inflammation stimulation, abnormal immune activation, destruction of thymic central tolerance and immune dysregulation were involved in the occurrence and pathogenesis of MG.
出处
《中国临床神经科学》
2017年第1期92-97,111,共7页
Chinese Journal of Clinical Neurosciences
基金
上海市卫计委重点项目(编号:201440019)
关键词
重症肌无力
胸腺
T细胞阳性选择
T细胞阴性选择
自身免疫反应
myasthenia gravis
thymus
positive selection of T ceil
negative selection of T cell
autoimmune response
