摘要
骨修复材料是当前临床应用需求量最大的生物医用材料之一.Ⅰ型胶原作为人体的主要结构蛋白,是骨组织的主要成分.胶原纤维所具有的独特四分之一错列结构能够引导纳米粒子沉积而实现矿化,因此常作为模板制备矿化胶原材料以模拟骨骼的多级微纳米结构,应用于骨修复领域.全文综述了矿化胶原材料的种类及制备,重点阐述了胶原纤维的矿化机制及调控因素,并简要展望了矿化胶原材料的发展前景及面临的挑战,为矿化胶原材料的制备及矿化机制的探索提供参考.
Bone repair material is one of the biomedical materials with the highest demand in clinical practice.As the main structural protein of the human body,type I collagen is the main component of bone tissue.The unique quarter staggered structure of collagen fibrils can guide the deposition of nanoparticles to achieve mineralization;therefore,collagen fibrils are often used as a template in the mineralization of collagen materials to mimic the multi-level micro and nano structures of bone for bone repair applications.In the present paper,the classification and preparation of mineralized collagen materials were reviewed and the mineralization mechanism and regulatory factors were emphasized.Finally,the development prospect and challenges of mineralized collagen materials were briefly prospected,which gave reference to the preparation of mineralized collagen materials and the exploration of mineralization mechanism.
作者
田振华
赵文杰
高盼盼
何静瑄
TIAN Zhen-hua;ZHAO Wen-jie;GAO Pan-pan;HE Jing-xuan(College of Bioresources Chemical and Materials Engineering,Shaanxi University of Science&Technology,Xi′an 710021,China;National Demonstration Center for Experimental Light Chemistry Engineering Education,Shaanxi University of Science&Technology,Xi′an 710021,China;Xingye Leater Technology Co.,Ltd.,Quanzhou 362000,China)
出处
《陕西科技大学学报》
北大核心
2023年第6期121-130,共10页
Journal of Shaanxi University of Science & Technology
基金
国家自然科学基金项目(22278256)
中国博士后科学基金项目(2022M722668)
陕西省教育厅专项科研计划项目(21JK0549)
陕西科技大学博士科研启动基金项目(BJ2016-85)。
关键词
矿化胶原材料
种类
制备
矿化机制
调控因素
mineralized collagen materials
classification
preparation
mineralization mechanism
regulatory factors
