摘要
药物性肝损伤(DILI)是指由化学药品、生物制品、中成药等按处方药或非处方药管理的药品,以及中药材、天然药物、保健品、膳食补充剂等产品,或其代谢产物乃至其辅料、污染物、杂质等所导致的肝损伤。DILI是最常见的药物不良反应之一,近年来我国DILI的发生率逐年升高,对患者的健康造成严重威胁。DILI临床表现多样、发病机制复杂,诊断及防治难度较大。文章对DILI的定义、流行病学、临床特征、诊疗进展进行综述。
Drug induced liver injury(DILI)refers to the liver injury caused by chemicals,biological products,traditional Chinese patent medicines and simple preparations and other drugs managed by prescription drugs or non prescription drugs,as well as Chinese medicinal materials,natural drugs,health products,dietary supplements and other products,or their metabolites and even their excipients,pollutants,impurities,etc.DILI is one of the most common Adverse drug reaction.In recent years,the incidence of DILI in China has increased year by year,posing a serious threat to the health of patients.The clinical manifestations of drug-induced liver injury are diverse,and the pathogenesis is complex,making diagnosis and prevention difficult.This article reviews the definition,epidemiology,clinical characteristics,and progress in diagnosis and treatment of DILI.
作者
马丹彤
段雪飞
Ma Dantong;Duan Xuefei(General Department of Beijing Ditan Hospital Affiliated to Capital Medical University,Beijing 100015,China)
出处
《中华全科医师杂志》
2023年第11期1204-1209,共6页
Chinese Journal of General Practitioners
关键词
药物性肝损伤
诊断
治疗
研究进展
Drug induced liver injury
Diagnosis
Treatment
Research progress
