摘要
骨质疏松症(OP)是一种代谢性骨病,好发于老年人群,其增加了骨折风险,严重危害人们的身体健康。随着社会老龄化加剧,OP的发病率也呈上升趋势,虽然对该病已经取得了一些研究成果,但其确切的病因及发病机制仍不完全清楚。近年来,长链非编码RNA(lncRNA)在OP中的作用成为研究热点。lncRNA是一种重要的调控因子,广泛参与机体的生理病理过程,其可通过调控间充质干细胞的分化及成骨细胞和破骨细胞的增殖、凋亡等过程影响OP的发生及转归。深入研究lncRNA参与OP的机制,有望为OP的诊断及治疗提供新思路。
Osteoporosis(OP)is a metabolic bone disease,which often occurs in the elderly.It increases the risk of fractures and seriously endangers people′s health.With the gradual aging of the society,the incidence of OP is also on the rise.Although some research results have been achieved on the disease,its exact etiology and pathogenesis are still not fully understood.In recent years,the role of long non-coding RNA(lncRNA)in OP has become a research hotspot.lncRNA is an important regulatory factor that is widely involved in the physiological and pathological processes of the body.It can affect the occurrence and prognosis of OP by regulating the differentiation of mesenchymal stem cells and the proliferation and apoptosis of osteoblasts and osteoclasts.In-depth research on the mechanism of lncRNA involved in OP is expected to provide new ideas for the diagnosis and treatment of OP.
作者
王亮
张虎林
汪小敏
杨超强
王宜灿
赖学倩
WANG Liang;ZHANG Hulin;WANG Xiaomin;YANG Chaoqiang;WANG Yican;LAI Xueqian(Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Orthopedics,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China)
出处
《医学综述》
CAS
2022年第20期3985-3990,共6页
Medical Recapitulate
基金
甘肃省自然科学基金(18JR3RA077)
兰州市卫生健康科技发展项目(2019-050)
兰州市人才创新创业项目(2020-RC-67)
甘肃中医药大学附属医院青年项目(gzfy-2019-18)。
