摘要
宫腔粘连是导致女性继发不孕及月经异常的常见原因之一,其发病机制复杂多样,是多种机制共同作用的结果。传统的宫腔粘连分离术及术后联合雌激素和物理屏障治疗是主要治疗手段,该治疗方法虽能缓解部分临床症状,但对于子宫内膜功能的恢复有限。间充质干细胞(MSCs)具有干性-多分化功能,临床前数据显示,MSCs疗效尚可,可成为一种新的治疗方法。随着研究深入发现,MSCs可旁分泌MSCs外泌体,其内含大量信使物质,参与细胞间信号传递,在恢复受损子宫内膜及其功能中显示出良好结果。目前干细胞疗法仍处于临床试验阶段,要实现外泌体疗法的临床转化仍需深入探索。
Intrauterine adhesion is one of the common causes of secondary infertility and abnormal menstruation in women,which has complex and varied pathogenesis and is the result of combined action of multiple mechanisms.Traditional intrauterine adhesion separation and postoperative combined estrogen and physical barrier therapy are the main treatment methods.Although this treatment can relieve some clinical symptoms,the recovery of endometrial function is limited.Mesenchymal stem cells(MSCs)have stemness-multidifferentiation function,and the preclinical data show that MSCs are effective and can be a new therapeutic method.With the deepening of the study,it′s found that MSCs can paracysecrete MSCs exosomes,which contain a large number of messenger substances involved in intercellular signal transmission,showing favorable results in the recovery of damaged endometrium and its function.At present,stem cell therapy is still in the clinical trial stage,and further exploration is needed to realize the clinical transformation of exosome therapy.
作者
邢明月
王厚梅
张思雯
肖子文
XING Mingyue;WANG Houmei;ZHANG Siwen;XIAO Ziwen(Guizhou Medical University,Guiyang 550004,China;Department of Obstetrics and Gynecology,Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China)
出处
《医学综述》
CAS
2023年第12期2311-2315,共5页
Medical Recapitulate
基金
贵州省科技计划项目(黔科合基础-ZK〔2022〕一般436)。
关键词
宫腔粘连
间充质干细胞
外泌体
Intrauterine adhesion
Mesenchymal stem cells
Exosomes
