摘要
背景:间充质干细胞在免疫调节和组织修复方面表现出了巨大的应用潜能。从经血中分离提取的经血源性间充质干细胞在具有间充质干细胞特性的同时,还具有获取便捷、低免疫原性和无伦理道德限制的优势,近年来备受研究人员的瞩目。目的:对经血源性间充质干细胞的生物学特性以及在多系统和疾病方面的应用进行概述。方法:应用计算机检索PubMed、中国知网期刊全文数据库和谷歌学术2000至2018年与经血源性间充质干细胞相关的文献,检索词为"endometrium;menstrual blood;mesenchymal stem cells"及"子宫内膜;经血;间充质干细胞"。结果与结论:经血源性间充质干细胞拥有非常强的自我更新和多向分化能力,能够调节免疫应答,增加血管生成并促进组织修复。经血源性间充质干细胞在免疫、生殖等系统以及代谢性疾病方面已有不同程度的研究进展。目前研究中关于经血源性间充质干细胞的作用机制解释还不够充分,进一步研究经血源性间充质干细胞的旁分泌作用,将对经血源性间充质干细胞在创伤和退行性疾病的治疗以及血管再生和组织修复方面产生重大意义。而在经血源性间充质干细胞的临床试验研究方面,经血源性间充质干细胞应用于人体的安全性、作用于病灶或调节免疫的持续时间、对于人体的长期影响,这些至关重要的问题都需要进一步研究探讨。
BACKGROUND:Mesenchymal stem cells have great application potentials in immune regulation and tissue repair.Recently,menstrual blood-derived mesenchymal stem cells have attracted the attention of researchers because of their advantages,including easy acquisition,low immunogenicity and no ethical restrictions.OBJECTIVE:To review the biological characteristics of menstrual blood-derived mesenchymal stem cells and their application in multiple systems and diseases.METHODS:Relevant articles published from 2000 to 2018 were searched in PubMed,CNKI and Google Scholar using the keywords of“endometrium;menstrual blood;mesenchymal stem cells”in English and Chinese,respectively.RESULTS AND CONCLUSION:Menstrual blood-derived mesenchymal stem cells have a strong potential in self-renewal and multilineage differentiation.These cells regulate immune responses,accelerate angiogenesis,and promote tissue repair.The use of menstrual blood-derived mesenchymal stem cells has varying degrees of achievements in the immune and reproductive systems and metabolic diseases.Mechanisms of action underlying menstrual blood-derived mesenchymal stem cells are still insufficient.Further investigations on the paracrine effect of menstrual blood-derived mesenchymal stem cells will be of great significance for the treatment of traumatic and degenerative diseases,angiogenesis and tissue repair.Clinical trials regarding some crucial issues,such as safety of menstrual blood-derived mesenchymal stem cells,duration of immunomodulation and long-term cell effects in the human body,are warranted in the future.
作者
常琦圆
谭季春
Chang Qiyuan;Tan Jichun(Second Department of Reproduction,Reproductive Center,Shengjing Hospital of China Medical University,Shenyang 110022,Liaoning Province,China;Key Laboratory for Reproductive Disorder and Fertility Remodeling of Liaoning Province,Shenyang 110022,Liaoning Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2019年第21期3432-3438,共7页
Chinese Journal of Tissue Engineering Research
基金
国家重点研发计划(2018YFC1002100)
项目参与人:谭季春
辽宁省重点研发计划指导计划项目(2018020222)
项目负责人:谭季春
中国医科大学学科建设项目重大专项建设计划(培育)(3110118033)
项目负责人:谭季春~~
关键词
经血源性间充质干细胞
干细胞
再生医学
生物学特性
免疫调节
组织修复
血管生成
旁分泌
menstrual blood-derived mesenchymal stem cells
stem cells
regenerative medicine
biological characteristics
immunomodulation
tissue repair
angiogenesis
paracrine
