摘要
支气管肺发育不良（ bronchopulmonary dysplasia,BPD）常见于早产儿。20世纪80年代以来随着医疗技术的提高,早产儿成活率逐渐升高,同时BPD发病率也逐渐增加。目前,BPD的常规治疗并不理想,故亟需寻求一种新创性疗法减轻BPD造成的呼吸系统损伤,提高生活质量。近年来,间充质干细胞（ mesenchymal stem cell,MSC）的研究为BPD的治疗提供了新切入点。该文就MSC治疗BPD的可能作用机制及目前研究现状进行了初步探讨。
Bronchopulmonary dysplasia（ BPD） is a chronic lung disease that commonly occurs in pre-term. Since the 1980s,with the advances in perinatal care,survival rate of preterm has been raised,while BPD continues to be a significant cause of morbidity and mortality for premature infants. However,the treatment effect of BPD is unsatisfactory. It is urgent to search for innovative ways to reduce the respiratory injury that caused by BPD as well as to improve the quality of life. In recent years,mesenchymal stem cells′（ MSC） research has pro-vided a new way for the treatment of BPD. This review primarily summarizes the current status of the MSC ther-apies and its possible mechanism on BPD.
出处
《国际儿科学杂志》
2016年第9期677-680,共4页
International Journal of Pediatrics
关键词
间充质干细胞
支气管肺发育不良
抗炎
再生修复
旁分泌
Mesenchymal stem cell
Bronchopulmonary dysplasia
Anti-inflammatory
Regenerative re-pair
Paracrine
