摘要
目的:探讨医用胶对肠穿孔修补的安全性和可行性。方法:根据修补方式不同分为观察组和对照组,观察组采用医用胶修补肠穿孔,对照组采用止血夹修补肠穿孔。离体猪肠实验使用30组离体新鲜离体猪肠,采用拉力计对比两组修补方式的抗拉能和修补时间;活体猪外科实验选用3月龄普通家猪24只,观察组和对照组各12只,外科手术模拟肠穿孔后进行肠修补,对比两组修补方法术中出血量、手术时间、术后第1 d体温和白细胞、肠漏发生率情况;活体猪内镜实验选用3月龄普通家猪24只,观察组和对照组各12只,内镜下人造肠穿孔后进行肠修补,对比两组修补方法术中出血量、手术时间、术后第1 d体温和白细胞、肠漏发生率。结果:离体猪肠实验中观察组和对照组最大拉力值和修补时间对比差异无统计学意义(t=-0.573、1.153,P>0.05);活体猪外科实验和活体猪内镜实验中,观察组手术时间和术中出血量少于对照组,差异有统计学意义(t=-2.946、-4.256、6.647、7.642,P<0.05);术后第1 d体温、白细胞和肠漏发生率差异无统计学意义(t=0.247,0.306;χ^(2)=0.381,P>0.05)。结论:医用胶在肠穿孔修补中具有安全性和可行性,具有一定的研究意义和临床应用价值。
Objective:To investigate the safety and feasibility of medical adhesive for intestinal perforation repair.Methods:The groups were divided into observation and control groups according to the different repair methods.The observation group used medical adhesive to repair the intestinal perforation,and the control group used hemostatic clips to repair the intestinal perforation.Isolated pig intestine experiments were conducted using 30 groups of isolated fresh isolated pig intestines,and a tensiometer was used to compare the tensile strength and repair time of the two repair methods.In vivo swine surgery experiment was performed on 24 normal domestic pigs at the age of 3 months,12 in the observation group and 12 in the control group,and intestinal repair was performed after surgical simulation of intestinal perforation.The amount of intraoperative bleeding,operative time,temperature and leukocytes in the first postoperative day,and the occurrence of intestinal leakage were compared between the two repair methods.Results:There was no statistically significant difference in the maximum tension value and repair time between the observation and control groups in the isolated pig intestine experiment(t=-0.573,1.153,P>0.05).In the in vivo porcine surgery experiment and in vivo porcine endoscopy experiment,the operative time and intraoperative bleeding in the observation group were less than those in the control group,with statistically significant differences(t=-2.946,-4.256,6.647,7.642,P<0.05).There was no statistically significant difference in the incidence of temperature,leukocytes and intestinal leakage in the 1st postoperative d(t=0.247,0.306;χ^(2)=0.381,P>0.05).Conclusion:Medical adhesive has safety and feasibility in intestinal perforation repair,and has certain research significance and clinical application value.
作者
董俊
卢嘉臻
汤得真
张华玉
张鸣青
Dong Jun;Lu Jiazhen;Tang Dezhen(Gastroenterology Department,The Ninety-ninth Hospital of the United Nations Logistics Support Force,Southeast Hospital affiliated to Xiamen University,Zhangzhou,Fujian,363000,China)
出处
《黑龙江医学》
2023年第21期2598-2601,共4页
Heilongjiang Medical Journal
基金
第一七五医院青年苗圃基金(17Y003)。
关键词
肠穿孔
动物实验
医用胶
止血夹
并发症
Bowel perforation
Animal experiments
Medical glue
Hemostatic clamp
Complications
