摘要
双硫死亡是恶性肿瘤的一种新的细胞死亡方式。细胞死亡方式包括坏死性凋亡、细胞凋亡、细胞焦亡和铁死亡、铜死亡等多种调节性细胞死亡和意外性细胞死亡。双硫死亡是当溶质载体家族7成员11(SLC7A11)蛋白高表达的细胞遭受葡萄糖饥饿时触发细胞发生死亡的一种新的细胞死亡机制。针对调节细胞死亡机制的鉴定和表征不仅能够促进人们对细胞稳态的基本理解,而且能为治疗恶性肿瘤提供重要思路。
Disulfidptosis is a new cell death mode in malignant tumors.Cell death has evolved from multiple regulatory cell death and accidental cell death,including apoptosis,cellular pyroptosis,necroptosis,and iron and copper death.Disulfidptosis is a new cell death mechanism that triggers cells to undergo cell death when cells with high expression of the solute carrier family 7 member 11(SLC7A11)protein are subjected to glucose starvation.The identification and characterization of mechanisms targeting the regulation of cell death not only promotes a fundamental understanding of cellular homeostasis,but also provides important ideas for the treatment of malignant tumors.
作者
王腾飞
陈乾
左石
WANG Tengfei;CHEN Qian;ZUO Shi(Clinical Medical College of Guizhou Medical University,Guiyang,Guizhou,550000;Department of Hepatobiliary Surgery,the Affiliated Hospital of Guizhou Medical University,Guiyang,Guizhou,550000;Department of Organ Transplantation,the Affiliated Hospital of Guizhou Medical University,Guiyang,Guizhou,550000)
出处
《实用临床医药杂志》
2023年第17期145-148,共4页
Journal of Clinical Medicine in Practice
基金
国家自然科学基金资助项目(82260535)。
关键词
恶性肿瘤
双硫死亡
发病机制
细胞死亡机制
malignant tumor
disulfidptosis
pathogenesis
cell death mechanism
