摘要
胶质瘤是成人最常见的原发脑肿瘤,其本质是一种多基因异常疾病。溶质载体家族7成员11(SLC7A11)是编码胱氨酸/谷氨酸反向转运体的核心成分,其表达受转录和翻译层面的调控。SLC7A11通过调节氧化应激与铁死亡介导胶质瘤细胞增殖、侵袭和放化疗抵抗。深入研究SLC7A11将为胶质瘤的治疗提供新的理论依据和治疗靶标。
Glioma is the most common primary brain tumor in adults and is essentially a polygenic abnormal disease.Solute carrier family 7 member 11(SLC7A11)is a core component of the cystine/glutamate transporter and its expression is regulated at the transcriptional and translational levels.SLC7A11 mediates glioma cells proliferation,invasion and chemoradiotherapy resistance through regulation of oxidative stress and ferroptosis.Deep study of SLC7A11 will provide new theoretical basis and therapeutic targets for the treatment of gliomas.
作者
孔春禹
孙鹏飞
Kong Chunyu;Sun Pengfei(Second Clinical Medical College of Lanzhou University,Lanzhou 730030,China;Department of Radiation Oncology,Second Hospital of Lanzhou University,Lanzhou 730030,China)
出处
《国际肿瘤学杂志》
CAS
2022年第10期604-607,共4页
Journal of International Oncology
