摘要
目的基于多中心、随机对照研究探讨牛黄上清片(体外培育牛黄)含服治疗咽喉炎的疗效。方法选取2021年4月-2022年4月北京市中西医结合医院、广州市红十字会医院、广州市第一人民医院、青岛市即墨中医医院收治的咽喉炎患者88例作为研究对象,采用随机数字表法分为用药组与安慰剂组,各44例。2组患者均予以阿莫西林克拉维酸钾分散片治疗,在此基础上,用药组44例予以牛黄上清片(体外培育牛黄)含服,安慰剂组44例则予以牛黄上清片模拟剂含服,2组均连续用药5 d。比较2组临床疗效、症状改善时间,治疗前及治疗2、5 d后视觉模拟评分法(VAS)评分,治疗前及治疗5 d后炎性指标,不良反应。结果用药组治疗总有效率为90.91%,高于安慰剂组的70.45%(χ^(2)=5.906,P=0.015)。用药组咽喉部黏膜充血水肿、干燥、异物感改善时间短于安慰剂组(P<0.01)。治疗2、5 d后,2组VAS评分较治疗前降低,且用药组低于安慰剂组(P<0.05或P<0.01)。治疗5 d后,2组血清白介素-6、白介素-10、肿瘤坏死因子-α及γ干扰素水平均较治疗前明显降低,且用药组低于安慰剂组(P<0.05或P<0.01)。用药组与安慰剂组不良反应总发生率比较,差异无统计学意义(2.27%vs.0,P=1.000)。结论牛黄上清片(体外培育牛黄)含服治疗咽喉炎的疗效显著,可快速改善患者的临床症状,减轻疼痛及炎性反应,且安全性较高。
Objective To analyze the clinical efficacy of bezoar supernatant tablets(cultivating bezoar in vitro)oral in the treatment of pharyngitis based on a multicenter randomized controlled study.Methods From April 2021 to April 2022,88 patients with pharyngitis who treated in Beijing Hospital of Integrated Traditional Chinese and Western Medicine,Guangzhou Red Cross Hospital,Guangzhou First People′s Hospital,Qingdao Jimo Hospital of Traditional Chinese Medicine were selected as the research objects.They were divided into the medication group and the placebo group,44 cases in each group.All patients were treated with amoxicillin and clavulanate potassium dispersible tablets,based on this,the medication group was treated with bezoar supernatant tablets(cultivating bezoar in vitro)oral,and the placebo group was treated with bezoar supernatant tablets simulant for oral administration,both groups were treated for 5 days.Clinical effect,improvement time of symptoms,VAS score before treatment and at 2,5 days after treatment,inflammatory indexes before treatment and at 5 days after treatment,and incidence of adverse reactions were compared between the two groups.Results Total effective rate of the medication group was 90.91%,which was higher than 70.45%of the placebo group(χ^(2)=5.906,P=0.015).Improvement time of throat mucosa congestion,edema,dryness and foreign body sensation in the medication group were significantly shorter than those in the placebo group(P<0.01).At 2,5 days after treatment,the VAS score of the two groups were significantly lower than those before treatment,and the medication group was lower than that of the placebo group(P<0.05 or P<0.01).Compared with those before treatment,serum levels of IL-6,IL-10,TNF-α,IFN-γafter 5 days of treatment in the two groups were significantly lower,and the indexes of the medication group were significantly lower than those of the placebo group(P<0.05 or P<0.01).There was no significant difference in the total incidence of adverse reactions between the medication group
作者
陈胜筠
吕路瑶
王宁
陈林
王实凡
CHEN Shengjun;LYU Luyao;WANG Ning;CHEN Lin;WANG Shifan(Beijing Hospital of Integrated Traditional Chinese and Western Medicine,Beijing 100089,China;不详)
出处
《临床合理用药杂志》
2023年第27期24-27,共4页
Chinese Journal of Clinical Rational Drug Use
关键词
咽喉炎
牛黄上清片
体外培育牛黄
含服
炎性反应
疼痛
安全性
治疗结果
Pharyngitis
Bezoar supernatant tablets
Cultivating bezoar in vitro
Oral
Inflammatory response
Pain
Safety
Treatment outcome
