摘要
目的:观察甘海胃康胶囊联合西药治疗气滞型老年胃溃疡的临床疗效及对炎症因子的影响。方法:采用随机数字表法将82例气滞型老年胃溃疡患者分为对照组与治疗组各41例。对照组给予常规西药治疗,治疗组在对照组基础上联合甘海胃康胶囊治疗。比较2组治疗前后中医证候积分、胃肠激素指标[胃泌素(GAS)、胃动素(MTL)、生长抑素(SS)]和炎症因子[白细胞介素(IL)-17、IL-23]水平;比较2组临床疗效、幽门螺杆菌(Hp)清除率、不良反应发生率及复发率。结果:治疗组总有效率、Hp清除率分别为97.56%、90.63%,高于对照组82.93%、70.00%(P<0.05)。2组治疗后胃脘疼痛、胸胁胀满、嗳气吞酸、烦躁易怒中医证候积分低于治疗前(P<0.05),治疗组治疗后中医证候积分低于对照组(P<0.05)。2组治疗后IL-17、IL-23、GAS、MTL水平均较治疗前降低(P<0.05),SS水平升高(P<0.05);治疗组治疗后炎症因子、GAS、MTL水平低于对照组(P<0.05),SS水平高于对照组(P<0.05)。治疗组不良反应发生率4.88%,低于对照组21.95%(P<0.05)。随访6个月,治疗组复发率5.00%,低于对照组20.59%(P<0.05)。结论:甘海胃康胶囊联合西药治疗气滞型老年胃溃疡疗效确切,能调节患者胃肠激素水平,抑制炎症因子分泌,降低复发率,安全性较高。
Objective:To observe the clinical effect of Ganhai Weikang Capsules combined with western medicine for elderly gastric ulcer of qi stagnation type and its effect on inflammatory factors.Methods:A total of 82 cases of senile patients with gastric ulcer of qi stagnation type were divided into the control group and the treatment group according to the random number table method,with 41 cases in each group.The control group was treated with routine western medicine,and the treatment group was additionally treated with Ganhai Weikang Capsules based on the treatment of the control group.Before and after treatment,the traditional Chinese medicine(TCM)syndrome scores,indexes of gastrointestinal hormones including gastrin(GAS),motilin(MTL),somatostatin(SS),and levels of inflammatory factors including interleukin(IL)-17 and IL-23 were compared between the two groups.The clinical effects,clearance rates of helicobacter pylori(Hp),incidence of adverse reactions and recurrence rates were compared between the two groups.Results:The total effective rate and Hp clearance rate were respectively 97.56%and 90.63%in the treatment group,higher than those of 82.93%and 70.00%in the control group(P<0.05).After treatment,TCM syndrome scores of distending and pain in gastric cavity,fullness in chest and hypochondrium,belching and acid reflux,and dysphoria and irascibility in the two groups were lower than those before treatment(P<0.05),and TCM syndrome scores in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of IL-17,IL-23,GAS and MTL in the two groups were decreased when compared with those before treatment(P<0.05),and SS levels were increased(P<0.05);the levels of inflammatory factors,GAS and MTL in the treatment group were lower than those in the control group(P<0.05),and SS level was higher than that in the control group(P<0.05).The incidence of adverse reactions was 4.88%in the treatment group,lower than that of 21.95%in the control group(P<0.05).After six-month follow-up,the recurre
作者
徐微
林小花
刘媛
何雪云
徐建光
XU Wei;LIN Xiaohua;LIU Yuan;HE Xueyun;XU Jianguang(Department of Gastroenterology,Quzhou People's Hospital,Quzhou Zhejiang 324000,China)
出处
《新中医》
CAS
2023年第17期112-116,共5页
New Chinese Medicine
关键词
老年胃溃疡
气滞型
甘海胃康胶囊
胃肠激素
炎症因子
Elderly gastric ulcer
Qi stagnation type
Ganhai Weikang Capsules
Gastrointestinal hormones
Inflammatory factors
