摘要
神经接口是神经系统与外界物理设备进行信息交互的关键器件,利用光、电、磁、声等多种模态信息的融合,以神经信息增强的形式,可对大脑网络进行高时空精度的神经动力学分析,植入式多模态神经接口在神经科学基础研究、神经疾病的生物光电子诊疗、脑机融合与交互等前沿领域中具有重要应用.首先介绍了最新基于光学方法和电生理技术的多模态神经记录和调控原理,接着回顾了光电神经探针研究进展,并归纳了光学成像和记录及电生理记录等多种模态神经数据分析处理的一般方法,最后对植入式多模态神经接口进行总结,展望了该领域当前面临的挑战和未来的发展趋势.
Significance The nervous system is composed of different types of neurons connected in a network.Neurons communicate with each other through electrochemical signals,and this dynamic interaction of neurons is the internal driving force of human perception,cognition,and behavior.Deciphering and understanding the meaning of various complex neural activities is of great significance in the frontiers of neurological disease diagnosis and treatment,neurological rehabilitation,fundamental brain science,and several braincomputer interface applications.To achieve this,it is critical to develop advanced neural interfaces capable of interacting with the dynamic neural activities and nervous system.Fundamental research in this field has rapidly increased over the past few decades as a result of advancements in neuroscience and neurotechnology.This research includes the development of innovative neural recording and modulation tools that have provided researchers with an early glimpse into previously unanswerable questions,such as determining how the mind works,or which have been recognized and funded by a host of initiatives.In recent years,the United States,European countries,Japan,and China have launched their own brain initiatives to support this emerging field.In the future,in order to completely understand the complex structural and functional nervous system,more powerful tools must be developed to record,transmit,and modulate signals using multiple approaches.These tools must have the ability to manipulate neuron cell types specifically while minimizing side effects such as“the observer effect.”Neurological disorders affect more than one billion people worldwide,accounting for 7%of the total global disease burden,and this number is expected to increase substantially as human life expectancy increases and with increased population aging.This is largely due to neuropsychiatric diseases(including Alzheimer s disease,Parkinson s disease,epilepsy,and so on)and cerebrovascular diseases,which impose a heavy burden on soci
作者
徐明亮
李芳媛
刘岳圻
张瑾慧
师亚洲
何飞
Xu Mingliang;Li Fangyuan;Liu Yueqi;Zhang Jinhui;Shi Yazhou;He Fei(Innovation and Integration Center of New Laser Technology,Shanghai Institute of Optics and Fine Mechanics,Chinese Academy of Sciences,Shanghai 201800,China;School of Physical Sciences,University of Science and Technology of China,Hefei 230026,Anhui,China;University of Chinese Academy of Sciences,Beijing 100049,China;Zhangjiang Laboratory,Shanghai 201210,China)
出处
《中国激光》
EI
CAS
CSCD
北大核心
2023年第15期147-174,共28页
Chinese Journal of Lasers
关键词
医用光学
生物医学成像
光电子学
光遗传学
脑血流动力学
神经接口
植入式器件
微纳加工
medical optics
biomedical imaging
optoelectronics
optogenetics
cerebral hemodynamics
neural interfaces
implantable devices
micro/nano-fabrication
