摘要
光动力疗法(PDT)作为选择性治疗恶性肿瘤和良性疾病的精准靶向疗法,已获得了广泛的临床应用。如何利用先进的光学成像技术实现对PDT剂量的实时监测,是开展PDT个性化精准治疗的理论基础。本文介绍了PDT治疗过程中光敏剂、氧、单线态氧以及血管响应等所需监测的4个重要参量,重点总结了用于实时监测PDT参量的光学成像技术,并比较分析了这些技术的优势和局限性,最后讨论了光学成像技术在PDT临床转化应用中面临的挑战。
Photodynamic therapy(PDT)has been widely used as a precise targeted therapeutic modality in the clinical treatments of malignant tumor and benign diseases.The utilization of advanced optical imaging techniques in the real-time quantification of PDT dosimetric parameters is essential in predicting PDT efficiency and providing personalized and precise treatment.In this study,four important parameters in PDT dosimetry were introduced(i.e.,photosensitizer,ground-state oxygen,singlet oxygen,and vascular response).Furthermore,the advanced optical imaging techniques currently developed for monitoring the aforementioned dosimetric parameters are summarized,and the advantages and limitations of each optical imaging technique is comparatively analyzed.Finally,challenges in clinical translation of optical imaging techniques to the clinical application of PDT are briefly discussed.
作者
李文博
沈毅
李步洪
Li Wenbo;Shen Yi;Li Buhong(Key Laboratory of Opto-Electronic Science and Technology for Medicine of Ministry of Education,Fujian Provincial Key Laboratory for Photonics Technology,Fujian Normal University,Fuzhou,Fujian 350007,China)
出处
《中国激光》
EI
CAS
CSCD
北大核心
2020年第2期84-94,共11页
Chinese Journal of Lasers
基金
国家自然科学基金(61520106015,61805040,61635014)
教育部科技创新团队(IRT-15R10)
福建省科技计划项目(2019Y4004,2019J05061)
福建省教育厅科研项目(JT180093)。
关键词
医用光学
光动力疗法
光学成像
剂量
监测
临床应用
medical optics
photodynamic therapy
optical imaging
dose
monitoring
clinical application
