摘要
多囊卵巢综合征(PCOS)是一种育龄期妇女常见的异质性内分泌疾病,多伴有高雄激素血症、性激素紊乱、胰岛素抵抗和肥胖等并发症,且精神疾病的发病率也会升高。研究表明,PCOS与脑-肠轴功能异常存在显著正相关性,通过调节脑-肠轴失衡可改善PCOS患者的性激素紊乱、代谢异常及抑郁焦虑等症状。脑-肠轴是肠内细菌与大脑间的双向通信系统,影响脑-肠轴的主要因素有脑肠肽、肠道菌群、HPA轴以及固有基因。目前现代中医药治疗PCOS效果显著。本文主要对脑-肠轴参与PCOS发病的主要影响因素及中医药干预的研究进展进行综述,为以后开展实验及临床治疗提供参考。
Polycystic ovary syndrome(PCOS)is a common heterogeneous endocrine disorder in women of reproductive age,mostly associated with complications such as hyperandrogenemia,sex hormone disorders,insulin resistance and obesity,and with an increased prevalence of psychiatric disorders.Studies have shown that there is a significant positive correlation between the onset of PCOS patients and abnormal brain-gut axis function.The brain-gut axis is a two-way communication system between bacteria in the intestine and the brain.By regulating the brain-gut axis imbalance,the symptoms of sex hormone disorders,metabolic Abnormalities and depression in PCOS patients can be improved.The main factors affecting the brain-gut axis are brain-gut peptides,intestinal flora,HPA axis and intrinsic genetic factors.Modern Chinese medicine treatment is remarkably effective in improving the symptoms of PCOS.By exploring the main influencing factors of the brain-gut axis involved in the pathogenesis of PCOS and the related research progress of Chinese medicine intervention,this paper mainly provides a reference for future experimental and clinical treatment.
作者
吴亚琪
种超杰
宋家乐
周燕园
WU Yaqi;CHONG Chaojie;SONG Jiale;ZHOU Yanyuan(School of Pharmacy,Guilin Medical University,Guilin 541199;School of Public Health,Guilin Medical University,Guilin 541199;Dept.of Clinical Nutrition,the Second Hospital Affiliated to Guilin Medical University,Guilin 541199;Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health,Affiliated Hospital of Guilin Medical University,Guilin 541001,China)
出处
《华夏医学》
CAS
2023年第4期13-19,共7页
Acta Medicinae Sinica
基金
国家自然科学基金项目(81860767)
广西自然科学基金项目(2022GXNSFAA035603)。
关键词
多囊卵巢综合征
脑-肠轴
肠道菌群
polycystic ovary syndrome
brain-gut axis
gut microbiota
