摘要
多囊卵巢综合征与肠道微生态密切相关。肠道微生态在中医证候方面的研究主要集中在脾虚证、肾阳虚衰证、湿热证、脾虚湿盛证等方面,其中与肠道菌群密切相关的胰岛素抵抗、代谢综合征的中医病机证候与多囊卵巢综合征的病机不谋而合,其共性阐释主要有:(1)阴阳失衡,同为发病根本;(2)"脑-肠"理论贯穿其中。现代作用机制方面,多囊卵巢综合征患者肠道微生态及通透性确有改变,且肠道菌群紊乱与相关临床症状密切相关,主要表现有:(1)高雄激素血症;(2)胰岛素抵抗;(3)肥胖。目前,多囊卵巢综合征的治疗仍集中在针对特定症状,还无法达到患者内环境稳态、子代健康的理想结果。肠道菌群作为内环境因素,可与宿主相互作用,多项研究已经证实,肠道菌群可能通过多种途径、多种因素参与多囊卵巢综合征的病理生理过程的发生和发展,但究竟谁是机理的引导者,尚未知晓。目前,国内关于中医药干预治疗对多囊卵巢综合征患者肠道微生态影响的临床研究报道较少,尚需进一步深入研究。
Polycystic ovary syndrome(PCOS)is closely related to intestinal microecology.The research of intestinal microecology in TCM syndrome mainly focuses on spleen deficiency syndrome,kidney yang deficiency and failure syndrome,dampness heat syndrome,spleen deficiency and dampness excess syndrome,etc.The TCM pathogenesis and syndrome of insulin resistance and metabolic syndrome closely related to intestinal flora do not coincide with the pathogenesis of PCOS.The explanations for something in common are as follows:(1)The imbalance of yin and yang is the root of the disease;(2)The"brain-intestine"theory runs through it.In terms of modern mechanism of action,intestinal microecology and permeability in patients with PCOS re indeed changed,and intestinal flora disorder is closely related to clinical symptoms,including:(1)hyperandrogenemia;(2)insulin resistance;(3)obesity.At present,the treatment of PCOS is still focusing on specific symptoms,and the ideal results of stable internal environment and healthy offspring cannot be achieved.As an internal environmental factor,intestinal flora can interact with host.Many studies have confirmed that intestinal flora may participate in the occurrence and development of pathophysiological process of PCOS through various ways and factors.However,it is still unknown who is the guide of the mechanism.However,there are few reports on the influence of TCM intervention on intestinal microecology in patients with PCOS.Therefore,further research is needed in the future.
作者
安洁
周琴
薛毅芳
AN Jie;ZHOU Qin;XUE Yi-fang(Traditional Chinese Medicine Hospital of Kunshan,Kunshan,Jiangsu,China,215300)
出处
《河南中医》
2021年第1期153-158,共6页
Henan Traditional Chinese Medicine
基金
江苏省中医药科技项目(YB201835)。
关键词
多囊卵巢综合征
肠道微生态
阴阳失衡
“脑-肠”理论
高雄激素血症
胰岛素抵抗
肥胖
polycystic ovary syndrome(PCOS)
intestinal microecology
yin-yang imbalance
"brain-intestine"theory
hyperandrogenism
insulin resistance
obesity
