摘要
目的调查岳阳市某三级甲等医院儿童急性呼吸道人偏肺病毒(human metapneumovirus,HMPV)感染状况及基因分型。方法对2019年7月—2020年6月该院因急性呼吸道感染(acute respiratory tract infections,ARTI)住院的14岁以下儿童患者,收集临床资料,采集鼻咽拭子标本。采用实时聚合酶链反应检测HMPV。对HMPV阳性样本进行M和F基因分型。分析ARTI儿童患者中HMPV感染特点及基因分型特征。结果3175份ARTI患儿鼻咽拭子标本中共检出60例HMPV阳性,阳性检出率为1.9%。HMPV感染患儿年龄23 d~8岁。1岁以下婴幼儿占比30.0%(18/60)。季节分布中以夏季(57.7%)和秋季(36.7%)为主,在春季未检出HMPV感染。60例HMPV感染患儿中,临床诊断主要为支气管炎(65.0%,39/60)和肺炎(26.7%,16/60),临床表现主要为发热(71.7%,43/60)和咳嗽(71.7%,43/60)。HMPV感染者中,HMPV A2b基因型占比为53.3%。结论HMPV感染好发于1岁以下婴幼儿,监测时间段内流行高峰发生在夏秋两季,支气管炎是HMPV患者的主要诊断。主要流行株为A2b型。
Objective To investigate the infection status and genotyping of human metapneumovirus(HMPV)in hospitalized children with acute respiratory tract infection(ARTI)in a grade-A tertiary hospital in Yueyang City.Methods Clinical data and nasopharyngeal swabs were collected from children under 14 years of age who were hospitalized with ARTI in the above-mentioned hospital from July 2019 to June 2020.HMPV was detected by real-time polymerase chain reaction.The HMPV-positive samples were genotyped for M and F.The infection characteristics and genotyping features of HMPV in children with ARTI were analyzed.Results A total of 60 children patients with ARTI were positive for HMPV in 3,175 nasopharyngeal swabs detected,with a positive detection rate of 1.9%.The patients with HMPV infection ranged in age from 23 days to 8 years.The proportion of infants under 1 year old was 30.0%(18/60).Summer(57.7%)and autumn(36.7%)were predominant in the seasonal distribution,and no HMPV infection was detected in spring.Among the 60 children with HMPV infection,the main clinical diagnoses were bronchitis(65.0%,39/60)and pneumonia(26.7%,16/60),and the main clinical manifestations were fever(71.7%,43/60)and cough(71.7%,43/60).In the patients infected with HMPV,the HMPV A2b genotype accounted for 53.3%.Conclusion HMPV infection was most common in infants under 1 year old.The prevalence peak occurred in summer and autumn during the monitoring period.Bronchitis was the main diagnosis of the HMPV patients.The main prevalent strain was A2b type.
作者
彭芬
杨毅
余飞跃
姜习新
PENG Fen;YANG Yi;YU Feiyue;JIANG Xixin(Yueyang Hospital Affiliated to Hunan Normal University/Yueyang Municipal People’s Hospital,Yueyang,Hunan 414000,China)
出处
《实用预防医学》
CAS
2023年第8期936-939,共4页
Practical Preventive Medicine
关键词
急性呼吸道感染
人偏肺病毒
儿童患者
临床特征
基因分型
acute respiratory tract infection
human metapneumovirus
pediatric patient
clinical characteristic
genetic typing
