摘要
目的：了解呼吸道合胞病毒下呼吸道感染（RSV-LRTI）住院患儿的临床特点,探讨其治疗及转归。方法：回顾性分析2010年1月至2013年12月住院的RSV-LRTI患儿的临床和病原学资料。结果：RSV-LRTI患儿共613例,其中男393例,女220例,年龄2个月～6岁,〉6个月患儿351例,占57.2%;121例（19.7%）有基础疾病,以先天性心脏病最多见,其次为早产和（或）低出生体质量。613例患儿均进行痰培养检查,245例行肺炎支原体抗体检测,15例行血培养检查。痰液中共检出细菌75株,其中革兰阴性菌48株（64.0%）;血培养1例阳性。503例使用抗生素,以头孢菌素类最多,占63.0%;单药治疗占62.6%,二联用药占19.4%。治疗时间〈1周208例（33.9%）,1～2周357例（58.2%）。治愈498例（81.2%）,好转103例（16.8%）,未愈自动出院12例（2.0%）,无死亡病例。结论：丽水地区RSV-LRTI主要见于6个月以下婴儿,19.7%合并有基础疾病,12.3%合并细菌感染,以革兰阴性菌感染最常见;63.0%使用头孢菌素治疗,多为单药治疗,疗程1～2周。
Objective： To understand the clinical characteristics of hospitalized children＇s respiratory syncytial virus acute lower respiratory infection（ RSV-LRTI）, and investigate the therapy and prognosis. Methods： Retrospective analysis of clinical and etiological data were performed in children with RSV-LRTI admitted to our hospital from January 2010 to December 2013. Results： Six hundreds and thirteen children met the diagnostic criteria of RSV-LRTI. Three hundreds and ninety three were male and two hundreds and twenty were female,aged from 2 months to 6 years old,and the proportion of children younger than 6 months was 57. 2%.Underlying diseases were observed in 121（ 19. 7%） children,congenital heart disease were most common,followed by premature birth and（ or） low birth weight. All cases were performed sputum pathogen detection,fifteen cases were also got blood cultures,and the Ig M antibodies of Mycoplasma pneumoniae were detected for 245 children. Seventy five strains of bacteria were identified from sputum,48（ 64. 0%） were Gram-negative bacteria,and blood culture was positive in 1 case. Five hundreds and three children were treated with antibiotics,and the cephalosporins utilization was up to 63. 0%. The use of one antibiotic accounted for 62. 6%,while the combination of two antibiotics accounted for 19. 4%. The course of treatment in 208（ 33. 9%） cases was less than one week,and 357 cases（ 58. 2%）were between one to two weeks. The outcome were 498 cases（ 81. 2%） cured,103 cases（ 16. 8%） improved,12 cases（ 2. 0%）discharged by themselves. Conclusion： RSV-LRTI was mainly occured in infants under 6 months and the underlying diseases were found in19. 7% of cases,12. 3% of cases were combination with bacterial infection,and the most common bacteria was Gram-negative bacteria.Cephalosporins treatment was used in 63. 0% of cases. The use of single antibiotics for 1 ～ 2 weeks was the usual choice.
出处
《儿科药学杂志》
CAS
2015年第12期15-19,共5页
Journal of Pediatric Pharmacy
基金
浙江省丽水市科技局公益性项目
项目编号2012JYZB98
关键词
呼吸道合胞病毒
急性下呼吸道感染
儿童
Respiratory syncytial virus
Acute lower respiratory infection
Children
