摘要
目的 探究儿童青少年抑郁症伴自杀倾向患者炎症因子的变化及风险因素.方法 回顾性分析本院2021年1月~2022年9月收治的150例青少年抑郁症患者的临床资料,依据贝克自杀意念量表(BSI-CV)评分分为A、B组,其中A组为伴随自杀意念,B组为不伴随自杀意念,另选取80例体检正常的青少年作为健康对照组.对比不同组别患者血清炎性因子水平,分析影响青少年抑郁症患者存在自杀倾向的危险因素.结果 (1)A组白细胞介素-6、CC趋化因子配体2、肿瘤坏死因子α、白细胞介素-1β(IL-1β)水平均高于B组与健康对照组(P<0.05);(2)抑郁症病程、精神病家族史、近期与父母关系、IL-1β水平与BSI-CV评分均为影响抑郁症患者存在自杀倾向的独立危险因素(P<0.05).结论 儿童青少年抑郁症伴自杀倾向患者表现为血清炎症因子的上升,这类患者出现自杀倾向与多种危险因素有关,需引起重视.
Objective To explore the risk factors of suicidal tendency in children and adolescents with depres-sion and their inflammatory factors levels.Methods The clinical data of 150 adolescents with depression admitted to our hospital from January 2021 to September 2022 were retrospectively analyzed and divided into groups A and B ac-cording to the Baker Suicide Ideation Scale(BSI-CV)score.Group A was accompanied by suicidal ideation and group B was not accompanied by suicidal ideation.Another 80 adolescents with normal physical examination were selected as healthy control group.The levels of serum inflammatory factors in different groups were compared to analyze the risk factors of suicidal tendency in adolescents with depression.Results s(1)The levels of interleukin-6,CC chemokine ligand 2,tumor necrosis factorαand interleukin-1β(IL-1β)in group A were higher than those in group B and those in healthy control group(P<0.05).(2)The course of depression,family history of psychosis,recent relationship with parents,IL-1βlevel and BSI-CV score were all independent risk factors for suicidal intention in patients with depres-sion(P<0.05).Conclusion The increase of serum inflammatory factors in children and adolescents with depression and suicidal tendencies is related to a variety of risk factors,which should be paid attention to.
作者
关海艳
石峰
高志涛
黄业晟
王丹青
GUAN Haiyan;SHI Feng;GAO Zhitao(Psychiatry Department,Xuchang Jian'an Hospital,Xuchang 461000,China)
出处
《国际精神病学杂志》
2023年第4期703-707,共5页
Journal Of International Psychiatry
关键词
青少年抑郁症
自杀倾向
炎症因子
影响因素
Adolescent depression
Suicidal tendency
Inflammatory factors
Risk factor
