摘要
目的 观察温阳通络法联合甲钴胺治疗痛性糖尿病周围神经病变(PDPN)的疗效。方法 将我院120例PDPN患者随机分成观察组与对照组各60例。对照组给予甲钴胺治疗,观察组给予甲钴胺联合温阳通络法治疗,治疗8周后,比较两组临床疗效、Toronto临床评分与视觉模拟评分法(VAS)评分、空腹血糖(FPG)、2 h口服葡萄糖耐量试验(2hPG)、糖化血红蛋白(HbA1c)水平、运动神经传导速度(MCV)、感觉神经传导速度(SCV)、白细胞计数(WBC)、血红蛋白(Hb)、丙氨酸氨基转移酶(ALT)、血肌酐(Cr)水平。结果 治疗后,观察组总有效率高于对照组(P <0.05)。两组Toronto临床评分、VAS评分、FPG、2hPG、HbA1c低于治疗前,MCV、SCV高于治疗前;观察组Toronto临床评分和VAS评分、FPG、2hPG、HbA1c低于对照组,观察组MCV、SCV高于对照组(P<0.05)。治疗前后两组WBC、Hb、ALT、Cr水平接近,差异无统计学意义(P>0.05)。结论 温阳通络法联合甲钴胺治疗PDPN患者,能改善周围神经病变和血糖水平,降低疼痛程度,增加周围神经传导速度,不影响肝肾功能、血常规,疗效显著。
Objective To observe the therapeutic effect of warming yang and dredging collaterals method combined with mecobalamin on painful diabetes peripheral neuropathy(PDPN).Methods A total of 120 PDPN patients were randomly divided into observation group and control group with 60 cases each.Control group was treated with mecobalamin,while observation group was treated with warming yang and dredging collaterals method on the basis of control group.The clinical efficacy,fasting blood glucose(FPG),2-hour oral glucose tolerance test(2hPG),glycosylated hemoglobin(HbA1c) levels,motor nerve conduction velocity(MCV),sensory nerve conduction velocity(SCV),white blood cell count(WBC),hemoglobin(Hb),alanine aminotransferase(ALT),and blood creatinine(Cr)levels were compared between two groups.Results After treatment,the total effective rate of observation group was higher than that of control group(P<0.05);the clinical and VAS scores,FPG,2hPG,and HbA1c of both groups were lower than before treatment,and were lower in observation group than those of control group;the MCV and SCV of both groups were higher than before treatment,and were higher in observation group than those in control group(P<0.05);the WBC,Hb,ALT,and Cr of the two groups before and after treatment were similar,and the difference was not statistically significant(P>0.05).Conclusion Warming yang and unblocking collaterals method combined with mecobalamin can improve peripheral neuropathy and blood glucose levels,reduce pain severity,increase peripheral nerve conduction velocity,and has no impact on liver and kidney function and blood routine on PDPN patients.The therapeutic effect is significant.
作者
邹丽妍
朱铎声
余江毅
逄雯丽
ZOU Li-yan;ZHU Duo-sheng;YU Jiang-yi;PANG Wen-li(Nanjing University of Chinese Medicine,Nanjing 210000;Qingdao Hiser Hospital Affiliated of Qingdao University/Qingdao Hospital of TCM,Qingdao 266033;Jiaozhou Hospital of TCM,Jiaozhou 266300;Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210001)
出处
《湖北中医药大学学报》
2023年第4期95-98,共4页
Journal of Hubei University of Chinese Medicine
基金
山东省中医药科技项目(项目编号:Q-2022005)。
关键词
痛性糖尿病周围神经病变
温阳通络法
甲钴胺
Painful diabetes peripheral neuropathy
Warming yang and dredging collaterals method
Mecobalamin
