摘要
盆腔炎性疾病(PID)是当今困扰我国女性生育生活的一种疾病,以迁延难愈,反复发作为主要特点,其发病机制与细胞凋亡、免疫力低下、代谢及血流变异常、菌群失衡等因素相关。该病的病理表现常以组织粘连及纤维化的慢性炎症渗出为主,炎症反应贯穿于PID发生发展的始终,因此干预炎症反应是治疗该病的重要手段。西医治疗本病方法单一,常以抗生素经验性用药,而抗生素的使用带来的耐药问题却没有解决,患者症状不能得到明显改善,盆腔组织粘连持续存在。传统中医在抗炎方面疗效显著,治疗常以体内体外相结合的方法,通过口服中药汤剂、外用中药灌肠、中药离子导入、针灸等方式联合治疗,通过调控体内相关信号通路的传导,影响炎症因子表达而起到相应的治疗作用。目前多数文章以中医药提高治疗PID效果为中心,缺乏中医药调控PID相关信号通路及发病机制的总结性记载。故该综述通过总结国内外相关文献,提出5条与该病发生相关的信号通路,即转化生长因子-β/Smads蛋白(TGF-β/Smads)信号通路、Janus酪氨酸激酶/信号转导和转录激活因子(JAK/STAT)信号通路、核转录因子-κB(NF-κB)信号通路、丝裂原活化蛋白激酶(MAPK)信号通路及Hippo信号通路,通过阐述PID的发病机制,为该病提供有效的治疗靶点及思路。
Pelvic inflammatory disease(PID)is an infection of women's reproductive organs,which lasts a long time and features frequent recurrence.It is mainly caused by apoptosis,low immunity,abnormal metabolism and blood rheology indexes,and bacterial imbalance.The pathological manifestations are tissue adhesion,fibrosis,and chronic inflammation,and inflammatory response occurs in the whole process of this disease.Therefore,interfering with the inflammatory response tends to be a solution.A few therapies are available in western medicine and antibiotics are commonly used.However,antibiotic resistance is still a bottleneck in the treatment and thus the symptoms of patients fail to be obviously relieved,with pelvic tissue adhesions remained.In the treatment of inflammation,traditional Chinese medicine has remarkable effect and internal-use and external-use medicines are both used,such as oral Chinese medicinal decoction,Chinese medicine enema,Chinese medicine iontophoresis,and acupuncture.They exert therapeutic effect by regulating the conduction of related signaling pathways and influencing the expression of inflammatory cytokines.At the moment,most articles focus on the efficacy of traditional Chinese medicine in the treatment of PID,and there is a lack of summary on traditional Chinese medicine regulation of relevant signaling pathways and the pathogenesis of PID.Therefore,by summarizing relevant research,this review proposed five signaling pathways related to the occurrence of this disease,namely,transforming growth factor-β/Smads protein(TGF-β/Smads)signaling pathway,Janus kinase/signal transducer and transcription activator(JAK/STAT)signaling pathway,nuclear factor-κB(NF-κB)signaling pathway,mitogen-activated protein kinase(MAPK)signaling pathway,and Hippo signaling pathway,and described the pathogenesis of this disease.Thereby,this study is expected to provide effective targets and ideas for the treatment of this disease.
作者
沈凡琪
韩延华
刘丽
SHEN Fanqi;HAN Yanhua;LIU Li(Heilongjiang University of Chinese Medicine,Harbin 150040,China;First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2023年第18期251-258,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
黑龙江省省属本科高校中央支持地方高校改革发展项目(2021ZYGLG001)
黑龙江省自然科学基金面上基金项目(H2015026)
国家中医药管理局第二批全国中医学术流派传承工作室建设项目(国中医药人教函[2019]62号)。
关键词
中医药
盆腔炎性疾病
信号通路
发病机制
研究进展
traditional Chinese medicine
pelvic inflammatory disease
signaling pathway
pathogenesis
research progress
