摘要
目的探讨喹硫平联合丙戊酸镁治疗双相情感障碍躁狂发作的临床疗效,以及对患者认知功能及炎性因子水平的影响。方法选取医院2020年1月至2022年1月收治的双相情感障碍躁狂发作患者100例,随机分为A组(33例)、B组(33例)、C组(34例),分别予喹硫平、丙戊酸镁及丙戊酸镁联合喹硫平,均治疗4周。结果C组总有效率为88.24%,显著高于A组的75.76%和B组的72.73%(P<0.05)。3组患者治疗后的贝克-拉范森林躁狂量表(BRMS)评分均显著低于治疗前(P<0.05),且C组显著低于A组和B组(P<0.05)。C组患者治疗后的持续性错误数(RPE)、持续性应答数(RP)、完成分类数(CC)、错误应答数(RE)、连续操作测验(CPT)、词语学习测验(HVLT-R)评分均显著优于A组和B组(P<0.05)。3组患者治疗后的白细胞介素1β和肿瘤坏死因子-α水平均显著低于治疗前(P<0.05),且C组显著低于A组和B组(P<0.05)。C组不良反应发生率为8.82%,低于A组的15.15%和B组的18.18%,但无显著差异(P>0.05)。结论喹硫平联合丙戊酸镁治疗双相情感障碍躁狂发作疗效良好,可改善患者的认知功能,抑制炎性因子表达,且安全性较高。
Objective To investigate the clinical efficacy of quetiapine combined with magnesium valproate in the treatment of bipolar disorder with manic episodes,and its effect on cognitive function and inflammatory factor levels.Methods A total of 100 patients with bipolar disorder with manic episodes admitted to the hospital from January 2020 to January 2022 were selected and randomly divided into group A(33 cases),group B(33 cases)and group C(34 cases),and were given quetiapine,magnesium valproate,and magnesium valproate combined with quetiapine,respectively.All the groups were treated for four weeks.Results The total effective rate in group C was 88.24%,which was significantly higher than 75.76%in group A and 72.73%in group B(P<0.05).After treatment,the scores of the Bech-Rafaelsen Mania Rating Scale(BRMS)in the three groups were significantly lower than those before treatment(P<0.05),and the score in group C was significantly lower than that in group A and that in group B(P<0.05).The number of perseverative responses errors(RPE),perseverative responses(RP),completed classifications(CC)and perseverative errors(RE),the scores of the Continuous Performance Test(CPT)and the Hopkins Verbal Learning Test-Revised(HVLT-R)in group C were significantly better than those in group A and those in group B(P<0.05).The levels of interleukin-1βand tumor necrosis factor-αin the three groups were significantly lower than those before treatment(P<0.05),and those in group C were significantly lower than those in group A and group B(P<0.05).The incidence of adverse reactions in group C was 8.82%,which was significantly lower than 15.15%in group A and 18.18%in group B(P<0.05).Conclusion Quetiapine combined with magnesium valproate is effective and safe in the treatment of bipolar disorder with manic episodes,which can improve the cognitive function,and inhibit the expression of inflammatory factors.
作者
钟丽
王艺
张清盛
ZHONG Li;WANG Yi;ZHANG Qingsheng(Zigong Hospital Affiliated to Southwest Medical University·Zigong Mental Health Center,Zigong,Sichuan,China 643020)
出处
《中国药业》
CAS
2023年第17期90-93,共4页
China Pharmaceuticals
基金
四川省卫生和计划生育委员会科研课题[17PJ388]。
关键词
喹硫平
丙戊酸镁
双向情感障碍
躁狂发作
认知功能
炎性因子
quetiapine
magnesium valproate
bipolar disorder
manic episode
cognitive function
inflammatory factor
