摘要
目的探讨碳酸锂联合无抽搐电休克治疗对遭受童年创伤双相情感障碍患者认知功能及社会行为的影响。方法选取医院2018年1月至2020年1月收治的遭受童年创伤双相情感障碍患者100例,随机分为观察组和对照组,各50例。两组患者均给予无抽搐电休克治疗,观察组患者加服碳酸锂片,均连续治疗3个月。结果观察组总有效率为92.00%,显著高于对照组的76.00%(P<0.05);治疗后,观察组患者的汉密尔顿抑郁量表-17(HAMD-17)评分、Young躁狂量表(YMRS)评分及社会功能缺陷筛选表(SDSS)评分均显著低于对照组(P<0.05),认知功能筛查量表(CASI)各项评分及大体功能评定量表(GAF)评分均显著高于对照组(P<0.05);观察组与对照组不良反应发生率相当(16.00%比10.00%,P>0.05)。结论碳酸锂联合无抽搐电休克治疗能改善遭受童年创伤双相情感障碍患者的抑郁、躁狂程度,提高认知功能和社会行为能力。
Objective To study the effect of lithium carbonate combined with non-convulsive electroconvulsive therapy on cognitive function and social behavior of patients with bipolar affective disorder after childhood trauma.Methods A total of 100 patients with bipolar affective disorder after childhood trauma in the hospital from January 2018 to January 2020 were selected and randomly divided into the observation group and the control group,50 cases in each group.The control group was treated with electroconvulsive therapy and the observation group was added with lithium carbonate on the basis of the control group.All patients were continuously treated for3 months.Results The total effective rate of the observation group was 92.00%,which was higher than 76.00%of the control group(P<0.05).After treatment,the Hamilton Depression Scale-17(HAMD-17)scores,Yong Mania Scale(YMRS)scores,and Social Deficiency Screening Table(SDSS)scores of the observation group were significantly lower than those of the control group(P<0.05).The scores of the Cognitive Function Screening Scale(CASI)and the Gross Function Assessment Scale(GAF)scores were significantly higher than those of the control group(P<0.05);the observation group and the control group had similar adverse reactions(16.00%vs.10.00%,P>0.05).Conclusion Lithium carbonate combined with non-convulsive electroconvulsive therapy can improve the degree of depression and mania in patients suffering from childhood trauma and bipolar disorder and improve cognitive function and social behavior.
作者
赵宣
赵栋
张佳
马丽景
ZHAO Xuan;ZHAO Dong;ZHANG Jia;MA Lijing(Shijiazhuang No.8 Hospital,Shijiazhuang,Hebei,China 050081)
出处
《中国药业》
CAS
2020年第20期67-69,共3页
China Pharmaceuticals
基金
河北省医学科学研究重点课题[20181082]。
关键词
双相情感障碍
童年创伤
无抽搐电休克治疗
碳酸锂
认知功能
社会行为
bipolar disorder
childhood trauma
non-convulsive electroconvulsive therapy
lithium carbonate
cognitive function
social behavior
