摘要
目的探讨喹硫平、丙戊酸钠联合重复经颅磁刺激治疗缓解期双相障碍的临床效果及对患者认知功能障碍的影响。方法选取医院2017年1月至2019年1月收治的缓解期双相障碍患者98例,按奇偶法分为观察组和对照组,各49例。两组患者均予重复经颅磁刺激治疗,观察组患者加服富马酸喹硫平片及丙戊酸钠缓释片(Ⅰ)治疗。两组患者均连续治疗4周。结果观察组总有效率为89.80%,明显高于对照组的73.47%(P<0.05);治疗后,观察组患者抑郁自评量表(SDS)评分、贝克-拉范森躁狂量表(BRMS)评分均明显低于对照组,认知功能筛查量表(CASI)各项(包括注意力、定向力、记忆力、思维流畅性、语言表达力等)评分均明显高于对照组(P<0.05),皮质醇(Cor)、三碘甲状腺原氨酸(T3)、促肾上腺皮质激素(ACTH)水平均明显低于对照组(P<0.05);观察组患者不良反应发生率为16.33%,与对照组的10.20%相当(P>0.05)。结论重复经颅磁刺激联合喹硫平、丙戊酸钠治疗缓解期双相障碍,能改善抑郁、躁狂症状,以及认知功能和神经内分泌功能。
Objective To investigate the effect of quetiapine and sodium valproate combined with repetitive transcranial magnetic stimulation on cognitive impairment in patients with bipolar disorder in remission period.Methods A total of 98 patients with bipolar disorder in remission period from January 2017 to January 2019 in the hospital were selected and randomly divided into the observation group and control group,49 cases in each group.The control group was treated with repetitive transcranial magnetic stimulation,while the observation group was treated with Quetiapine Tablets and Sodium Valproate Tablets on the basis of repetitive transcranial magnetic stimulation.Both groups were treated for 4 consecutive weeks.Results The total effective rate of the observation group was 89.80%,which was significantly higher than 73.47%of the control group(P<0.05).After treatment,the self-rating depression scale(SDS)scores and Bech-Rafaelsen mania rating scale(BRMS)scores of the observation group were significantly lower than those of the control group,and the scores of the cognitive abilities screening instrument(CASI)items(including attention,orientation,memory,thinking fluency,language expression,etc.)were significantly higher than those of the control group(P<0.05);the levels of cortisol(Cor),triiodothyronine(T3),adrenocorticotropin hormone(ACTH)were significantly lower than those of the control group(P<0.05).The incidence of adverse reactions in the observation group was 16.33%,which was equivalent to 10.20%of the control group(P>0.05).Conclusion Repetitive transcranial magnetic stimulation combined with quetiapine and sodium valproate in the treatment of bipolar disorder in remission period can improve depression,manic symptoms,cognitive function and neuroendocrine function.
作者
邓巧恩
赵俊霞
刘光伟
赵栋
綦航
DENG Qiaoen;ZHAO Junxia;LIU Guangwei;ZHAO Dong;QI Hang(Shijiazhuang Eighth Hospital,Shijiazhuang,Hebei,China 050000)
出处
《中国药业》
CAS
2020年第8期138-141,共4页
China Pharmaceuticals
基金
河北省医学科学研究重点课题[20181082]。
关键词
双相障碍
缓解期
重复经颅磁刺激
喹硫平
丙戊酸钠
认知功能
临床疗效
bipolar disorder
remission period
repetitive transcranial magnetic stimulation
quetiapine
sodium valproate
cognitive function
clinical efficacy
