摘要
目的探究齐拉西酮联合碳酸锂对双相情感障碍躁狂发作患者疗效、认知功能及神经递质水平的影响。方法选取2020年7月至2022年7月绍兴市第七人民医院收治的80例双相情感障碍躁狂发作患者,采用随机数字表法分为对照组(n=40)和联合组(n=40)。对照组给予碳酸锂,联合组给予齐拉西酮联合碳酸锂治疗。比较两组Bech-Rafaelsen躁狂量表(Bech-Rafaelsen mania rating scale,BRMS)评分、整体治疗效果、认知功能、神经递质水平、炎症因子水平及不良反应。结果联合组的治疗总有效率显著高于对照组(P<0.05)。与治疗前比较,治疗后两组的BRMS评分、白细胞介素-1β、肿瘤坏死因子-α、深抑制递质、乙酰胆碱水平均显著降低(P<0.05),且联合组低于对照组(P<0.05);治疗后两组的持续性操作测验评分、γ-氨基丁酸、多巴胺、白细胞介素-10水平均明显升高,且联合组显著高于对照组(P<0.05);两组治疗前后言语记忆测验、威斯康星卡片分类测验评分及不良反应情况比较,差异均无统计学意义(P>0.05)。结论齐拉西酮联合碳酸锂治疗双相情感障碍躁狂发作,可有效改善患者临床症状,提高认知功能,减轻炎症反应,调节神经递质水平,安全有效。
Objective To investigate the influences of ziprasidone combined with lithium carbonate on curative effect,cognitive function and neurotransmitter levels of manic episodes with bipolar disorder in patients.Methods A total of 80 patients of manic episodes with bipolar disorder admitted to the Shaoxing 7th People’s Hospital from July 2020 to July 2022 were selected and divided into a control group(n=40)and a combined group(n=40)according to the random number table method.The control group was given lithium carbonate,and the combined group was given ziprasidone combined with lithium carbonate.The Bech-Rafaelsen mania rating scale(BRMS),overall treatment effect,and cognitive function,neurotransmitter levels,inflammatory factor levels and adverse reactions were compared between the two groups.Results The total effective rate of the combined group was significantly higher than that of the control group(P<0.05).Compared with before treatment,the BRMS score,interleukin-1β,tumor necrosis factor alpha,deep inhibitory transmitter,and acetylcholine levels of both groups were significantly decreased after treatment(P<0.05),and were significantly lower in the combination group than those in the control group(P<0.05).After treatment,the continuous performance test(CPT)score,γ-aminobutyric acid,dopamine,and interleukin-10 levels in the two groups were significantly increased,and were significantly higher in the combination group than those in the control group(P<0.05).There was no statistically significant difference in Hopkins verbal learning test-revised(HVLT-R)and Wisconsin card sorting test scores between the two groups before and after treatment(P>0.05).Conclusion Ziprasidone combined with lithium carbonate for manic episodes with bipolar disorder can effectively improve clinical symptoms,enhance cognitive function,reduce inflammatory response,and regulate neurotransmitter levels,which is safe and effective.
作者
谢炎
冯虹
谢小莉
沈金辉
XIE Yan;FENG Hong;XIE Xiaoli;SHEN Jinhui(Department of Pharmacy,Shaoxing 7th People’s Hospital,Shaoxing 312000,Zhejiang,China;Sleep Ward of Integrated Traditional Chinese and Western Medicine,Shaoxing 7th People’s Hospital,Shaoxing 312000,Zhejiang,China)
出处
《中国现代医生》
2023年第20期68-71,88,共5页
China Modern Doctor
基金
浙江省卫生健康科技计划(2022RC279)。
关键词
双相情感障碍躁狂发作
认知功能
碳酸锂
神经递质
齐拉西酮
Manic episodes with bipolar disorder
Cognitive function
Lithium carbonate
Neurotransmitters
Ziprasidone
