摘要
目的观察连柴除幽汤联合改良二联疗法对肝胃不和型Hp感染的临床疗效。方法选取2021年1月至2022年1月就诊于重庆市中医院南桥寺院区经C13或C14呼气试验证实有Hp感染且符合中医肝胃不证的患者,按照治疗方法不同分为对照组(四联组)、观察组1(二联组)、观察组2(中西组)3组,每组60例。分别予连柴除幽汤联合改良二联疗法、二联疗法、四联疗法治疗14 d,比较3组Hp根除率、中医症候疗效、不良反应发生率。结果治疗后3组根除率比较,差异有统计学意义(P<0.05),且二联组、中西组高于四联组(P<0.05)。与治疗前比较,3组治疗后症状总评分低于治疗前,且中西组治疗后症状总评分低于二联组,二联组低于四联组(P<0.05)。四联组、二联组、中西组总有效率分别为66.67%、82.76%、91.52%。四联组与中西组95%CI无重叠,则中西组治疗疗效高于四联组;四联组与二联组95%CI存在重叠,二联组与中西组95%CI存在重叠,提示四联组与二联组、二联组与中西医组总有效率比较,差异无统计学意义(P>0.05)。共14例患者出现不良反应,3组不良反应发生率比较,差异无统计学意义(P>0.05)。结论对于Hp感染肝胃不和型患者,更推荐使用连柴除幽汤联合改良二联疗法治疗。
Objective To observe the clinical efficacy of Lianchai Chuyou Decoction combined with modified dual therapy in the treatment of patients with Hp infection.Methods Patients with Hp infection confirmed by C13 or C14 breath test in Nanqiao Temple District,Chongqing Hospital of Traditional Chinese Medicine from January 2021 to January 2022 were selected and divided into control group(quadruple group),observation group 1(binary group)and observation group 2(Central and Western group)according to different treatment methods,with 60 cases in each group.Lianchai Xiaoyou Decoction combined with modified double therapy,double therapy and quadruple therapy were treated for 14 days,and the eradication rate of Hp,the efficacy of TCM symptoms and the incidence of adverse reactions were compared among the three groups.Results After treatment,the eradication rate of the three groups was statistically significant(P<0.05),and the two groups were higher than the four groups(P<0.05).Compared with before treatment,the total symptom score of the 3 groups after treatment was lower than that before treatment,and the total symptom score of the Chinese and western groups after treatment was lower than that of the binary group,and that of the binary group was lower than that of the four-group(P<0.05).The total effective rates were 66.67%,82.76%and 91.52%in the four group,the two group and the central and western group,respectively.There was no overlap of 95%CI between the four groups and the Chinese and western groups,so the therapeutic effect of the Chinese and western groups was higher than that of the four groups.There was an overlap of 95%CI between the four group and the two groups,and there was an overlap between the two groups and the Chinese and western groups,suggesting that there was no statistical significance in the total effective rate between the four group and the two groups,and between the two groups and the Chinese and western groups(P>0.05).A total of 14 patients had adverse reactions,and there was no statistical signific
作者
宋梦如
杨小军
SONG Mengru;YANG Xiaojun(Guangci Branch,The First Affiliated Hospital of Soochow University,Suzhou,Jiangsu 215000,China;Chongqing Hospital of Traditional Chinese Medicine,Chongqing 400000,China)
出处
《重庆医学》
CAS
2023年第S01期55-59,共5页
Chongqing medicine
基金
重庆市自然科学基金项目(cstc2021jcyj-msxmX0858)。
关键词
连柴除幽汤
改良二联疗法
HP感染
疗效评价
Lianchai Chuyou decoction
modified dual therapy
Hp infection
efficacy evaluation
