摘要
目的探究含铋剂四联方案治疗幽门螺杆菌(Hp)感染的效果,分析对患者血清炎症因子水平的影响。方法回顾性分析2021年1月至2021年12月我院收治的Hp感染者100例,采用数字列表法随机分为对照组和观察组各50例。对照组给予克拉霉素、雷贝拉唑、阿莫西林三联疗法,观察组给予胶体果胶铋、克拉霉素、雷贝拉唑、阿莫西林四联疗法。对比两组Hp根除率、不良反应及血清肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)、白细胞介素6(IL-6)水平变化。结果治疗前,两组患者TNF-α、CRP、IL-6水平比较,差异无统计学意义(P>0.05);治疗14天后,两组患者TNF-α、CRP、IL-6水平较治疗前均显著降低,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组患者Hp根除率为96.0%,显著高于对照组的76.0%,差异有统计学意义(P<0.05)。两组治疗不良反应发生率比较,差异无统计学意义(P>0.05)。结论相对于标准三联方案,含铋剂四联方案能有效提升患者Hp根除率,且不会增加患者的不良反应。
Objective To explore the effect of bismuth-based quadruple therapy in the treatment of Helicobacter pylori(HP)infection,and analyze its effect on the level of serum inflammatory factors.Methods A total of 100 patients with HP infection admitted to our hospital from January 2021 to December 2021 were retrospectively analyzed.They were randomly divided into control group and observation group by numerical list method,with 50 cases in each group.The control group was treated with clarithromycin,rabeprazole and amoxicillin,while the observation group was treated with colloidal bismuth pectin,clarithromycin,rabeprazole and amoxicillin.HP eradication rate,adverse reactions and serum tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and interleukin 6(IL-6)levels were compared between the two groups.Results Before treatment,there was no significant difference in the levels of TNF-α,CRP and IL-6(P>0.05).After 14 days of treatment,the levels of TNF-α,CRP and IL-6 levels in both groups were significantly lower than those before treatment,and those in observation group were significantly lower than those of the control group(P<0.05).The eradication rate of HP in the observation group was 96.0%,which was significantly higher than 76.0%in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Compared with the standard triple regimen,the bismuth-based quadruple regimen can effectively improve the HP eradication rate of patients without increasing the adverse reactions.The bismuth-based quadruple regimen can effectively improve the HP eradication rate of patients,which may be related to the improvement of inflammatory symptoms.
作者
陶涛
闵捷
TAO Tao;MIN Jie(Medical department,The Third Hospital of Nanchang,Nanchang 330000 China;Office of drug clinical trial institution,The Third Hospital of Nanchang,Nanchang 330000 China)
出处
《现代诊断与治疗》
CAS
2022年第20期3003-3006,共4页
Modern Diagnosis and Treatment
