摘要
目的研究前列舒通联合盐酸坦索罗辛治疗慢性前列腺炎(CP)的疗效及对患者血清前列腺特异性抗原(PSA)、神经生长因子(NGF)、转化生长因子(TGF-β)的影响。方法选取2021年3月-2022年3月天津市宝坻区人民医院泌尿外科收治的82例CP患者,采用随机数字表法分为对照组(41例)与观察组(41例)。对照组给予盐酸坦索罗辛治疗,观察组采用前列舒通联合盐酸坦索罗辛治疗。比较两组临床疗效、慢性前列腺炎症状评分(NIH-CPSI)、血清PSA、NGF、TGF-β水平、前列腺液炎性因子[白介素-8(IL-8)、肿瘤坏死因子α(TNF-α)]水平。结果观察组总有效率高于对照组(P<0.05);观察组治疗后NIH-CPSI评分3个方面(疼痛或不适症状、排尿症状、症状对生活质量的影响)均低于对照组(P<0.05);观察组治疗后血清PSA、NGF、TGF-β水平低于对照组,前列腺液IL-8、TNF-α水平低于对照组(P<0.05)。结论前列舒通联合盐酸坦索罗辛治疗CP疗效肯定,可有效改善患者症状,下调机体PSA、NGF、TGF-β水平,减轻炎性反应,值得临床应用。
Objective To study the efficacy of Qianlie Shutong combined with tamsulosin hydrochloride in the treatment of chronic prostatitis(CP)and its effect on serum prostate specific antigen(PSA),nerve growth factor(NGF)and transforming growth factor(TGF-β).Methods A total of 82 patients with CP admitted to the Department of Urology,Tianjin Baodi District People's Hospital from March 2021 to March 2022 were selected and divided into control group(41 patients)and observation group(41 patients)by random number table method.The control group was treated with tamsulosin hydrochloride,and the observation group was treated with Qianlie Shutong combined with tamsulosin hydrochloride.The clinical efficacy,chronic prostatitis symptom score(NIH-CPSI),serum PSA,NGF,TGF-βlevels,prostatic fluid inflammatory factors[interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)]levels were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the NIH-CPSI scores in three aspects(pain or discomfort symptoms,urination symptoms,and effects of symptoms on quality of life)of the observation group were lower than those of the control group(P<0.05).After treatment,the levels of serum PSA,NGF and TGF-βin the observation group were lower than those in the control group,and the levels of IL-8 and TNF-αin prostatic fluid were lower than those in the control group(P<0.05).Conclusion Qianlie Shutong combined with tamsulosin hydrochloride is effective in the treatment of CP,which can effectively improve the symptoms of patients,down-regulate the levels of PSA,NGF and TGF-β,and reduce the inflammatory response.It is worthy of clinical application.
作者
孙鹏飞
王华东
SUN Peng-fei;WANG Hua-dong(Department of Urology Surgery,Baodi District People's Hospital,Tianjin 301800,China)
出处
《医学信息》
2023年第15期144-147,共4页
Journal of Medical Information
