摘要
天然免疫又称固有免疫、非特异性免疫。单核巨噬细胞、自然杀伤细胞、树突状细胞等细胞参与构成天然免疫系统。肺纤维化是间质性肺疾病的终末期病理改变,临床常表现为进行性加重的呼吸困难、限制性通气功能障碍伴弥散功能降低、低氧血症。肺纤维化的形成过程可分为肺泡上皮细胞损伤、成纤维细胞增殖、成纤维细胞向肌成纤维细胞转化和细胞外基质沉积4个阶段。天然免疫细胞参与肺纤维化形成的各个阶段,研究天然免疫细胞对肺纤维化的治疗具有重要意义。
Natural immunity is also known as innate immunity and nonspecific immunity.Macrophages,natural killer cells,dendritic cells and other cells are involved in the nonspecific immune system.Pulmonary fibrosis is the end-stage pathology of interstitial lung disease which often presents with progressive dyspnea,restrictive ventilatory dysfunction with reduced diffusion and hypoxemia.The process of pulmonary fibrosis formation can be divided into four stages:alveolar epithelial cell injury,fibroblast proliferation,fibroblast-to-myofibroblast transformation,and extracellular matrix deposition.Innate immune cells are involved in all stages of pulmonary fibrosis formation,and it is important to study natural immune cells for the treatment of pulmonary fibrosis.
作者
王文捷
徐宸桢
李宁
耿庆
Wang Wenjie;Xu Chenzhen;Li Ning;Geng Qing(Department of Thoracic Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《中华实验外科杂志》
CAS
北大核心
2023年第6期1225-1228,共4页
Chinese Journal of Experimental Surgery
关键词
天然免疫
巨噬细胞
肺纤维化
外泌体
Innate immunity
Macrophage
Pulmonary fibrosis
Exosome
