摘要
目的:研究王行宽教授治疗不寐病的用药经验及处方规律以传承其诊疗不寐病的经验。方法:收集王行宽教授2017年1月1日至2021年12月31日诊治不寐病的原始医案资料,通过中医传承计算平台V3.0进行分析,采用频数统计、关联规则、无监督学习的k-means算法进行证候、治法、四气、五味、归经、药物功效、用药的频数统计,并进行组方规律分析和药物核心组合分析。结果:共收集王行宽教授治疗不寐病处方827份,所用药物四气以寒、平为主,五味以甘、苦为主,归经以肺经、心经、脾经为主;高频药物主要为茯神、半夏、酸枣仁、柴胡、炙甘草、麦冬、远志、五味子、天麻等;组方规律分析得到常用药物组合22个,置信度≥0.9的组合有13个,并得到常见证型核心药物;药物聚类分析得到4个核心药物组合。结论:王行宽教授论治不寐病以益气养阴、养心安神、疏肝利胆、清热化痰为治法,用方以百合安神汤加减化裁为主,并根据病机以分证论治。
Objective:To study Professor WANG Xingkuan's medication experience and prescription rules in the treatment of insomnia,in order to inherit his experience in diagnosing and treating insomnia.Methods:The original medical records of Professor WANG Xingkuan's diagnosis and treatment of insomnia from January 1,2017 to December 31,2021 were collected and analyzed through traditional Chinese medicine inheritance computing platform V3.0.The k-means algorithm based on frequency statistics,association rules and unsupervised learning was used to carry out manifestation of syndrome,treatment principle and method,four Qi,five flavors,meridian tropism,drug efficacy,medication frequency statistics,and carry out formula rule analysis,and drug core combination analysis.Results:A total of 827 prescriptions of Professor WANG Xingkuan for insomnia were collected.The drugs used are mainly cold and flat in four Qi,sweet and bitter in five flavors,and lung meridian,heart meridian and spleen meridian in meridian tropism.High frequency drugs mainly include Fushen(Poria cum Pini Radice),Banxia(Pinelliae Rhizoma),Suanzaoren(Ziziphi Spinosi Semen),Chaihu(Bupleuri Radix),Zhigancao(Glycyrrhizae Radix cum Liquido Fricta),Maidong(Ophiopogonis Radix),Yuanzhi(Polygalae Radix),Wuweizi(Schisandrae Fructus),and Tianma(Gastrodiae Rhizoma),etc.22 commonly used drug combinations were obtained through the analysis of formula rule analysis,13 combinations of them with confidence level≥0.9,and the core drugs of common syndrome types were obtained.Four core drug combinations were obtained through drug cluster analysis.Conclusion:Professor WANG Xingkuan's treatment of insomnia was based on the principles of Supplementing Qi and nourishing Yin,nourishing the heart and calming the nerves,soothing the liver and gallbladder,clearing heat and resolving phlegm.The prescription was mainly Baihe Anshen Decoction(百合安神汤)plus variation,and was treated according to the pathogenesis.
作者
王子焱
周婕
刘承鑫
范金茹
郭志华
WANG Ziyan;ZHOU Jie;LIU Chenxin;FAN Jinru;GUO Zhihua(The First Hospital of Hunan University of Chinese Medicine,Changsha Hunan 410007,China;Hunan University of Chinese Medicine,Changsha Hunan 410208,China;Hunan Key Laboratory of Intelligent Traditional Chinese Medicine Diagnosis and Preventive Treatment of Chronic Diseases of Hunan Universities of Chinese Medicine,Changsha Hunan 410208,China)
出处
《中医药导报》
2023年第7期154-160,共7页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
国家中医药管理局·湖南省中医药管理局“王行宽全国名中医传承工作室”建设项目(国中医药办人教函〔2018〕119号)
湖南省中医药科研计划重点项目(201716)
湖南省教育厅科学研究项目(16A159)。
关键词
不寐病
王行宽
数据挖掘
经验总结
用药规律
insomnia
WANG Xingkuan
data mining
experience summary
medication rules
