摘要
肠道微生物伴随宿主一生,对宿主的消化吸收以及肠道健康产生巨大影响。肠道微生物的动态平衡维护宿主稳态,而肠道微生物失调会引起宿主肠道相关疾病。分泌型免疫球蛋白A(secretory IgA,SIgA)作用于肠道微生物,影响其组成、代谢和定植,调节肠道微生物的动态平衡。SIgA与肠道微生物的互作维持了肠道微生物与宿主的互利共生。然而,目前对于SIgA与肠道微生物的互作机制还缺乏系统解析。本文从SIgA的产生机制、肠道微生物对SIgA的诱导以及降解作用、SIgA对肠道微生物的组成及定植的影响进行阐述,主要综述SIgA与肠道微生物的相互作用,以期为肠道微生物相关疾病的机理阐释及检测治疗提供理论依据。
Gut microbiota accompanies the host's life and has a huge impact on the host's digestion,absorption and intestinal health.The dynamic balance of gut microbiota maintains host homeostasis,while gut microbiota dysbiosis causes host gut-related diseases.Secretory immunoglobulin A(SIgA)acts on gut microbiota,affecting their composition,metabolism,and colonization,and regulating the homeostasis of gut microbiota.The interaction between SIgA and gut microbiota maintains the mutual symbiosis between gut microbiota and the host.However,there is still a lack of systematic analysis of the interaction mechanism between SIgA and gut microbiota.In this review,we focus on the production mechanism of SIgA,the induction and degradation of SIgA,the effects of SIgA on the composition of intestinal microbiota and colonization,and mainly review the interaction between SIgA and intestinal microbiota to provide a theoretical basis for the mechanism interpretation and detection and treatment of intestinalmicrobiota-relateddiseases.
作者
吴元霞
孙静
葛良鹏
李周权
张进威
WU Yuan-Xia;SUN Jing;GE Liang-Peng;LI Zhou-Quan;ZHANG Jin-Wei(Key Laboratory for Bio-Feed and Molecular Nutrition,College of Animal Science and Technology,Southwest University,Chongqing 400715,China;Chongqing Academy of Animal Sciences,Chongqing 402460,China;Key Laboratory of Pig Raising Science,Ministry of Agriculture,Chongqing 402460,China)
出处
《生命科学》
CSCD
北大核心
2023年第6期733-742,共10页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(32072687)
四川省国际科技创新合作/港澳台科技创新合作项目(2021YFH0033)
重庆市自然科学基金面上项目(cstc2021jcyj-msxmX0630)
重庆市科研机构绩效引导专项(23508J)
四川省科技厅区域创新合作项目(2022YFQ0022)。
关键词
分泌型免疫球蛋白A
产生机制
肠道微生物
定植
互作
secretory immunoglobulin A
generation mechanism
gut microbiota
colonization
interactions
