摘要
目的探讨MRI扩散峰度成像(diffusion kurtosis imaging,DKI)参数与鼻咽癌(nasopharyngeal carcinoma,NPC)临床分期的相关性。方法86例经病理证实为NPC患者,均行DKI扫描,DKI参数包括弥散各向异性(fractional anisotropy,FA)、平均弥散系数(mean diffusivity,MD)、轴向弥散系数(axial diffusivity,Da)、径向弥散系数(radial diffusivity,Dr)、平均弥散峰度(mean kurtosis,MK)、轴向弥散峰度(axial kurtosis,Ka)、径向弥散峰度(radial kurtosis,Kr)、弥散峰度各向异性(FA of kurtosis,FAK)值,两位观察者对肿瘤病灶DKI各参数值测量的一致性采用组内相关系数(intraclass correlation coefficient,ICC)进行检验,分析DKI各参数与NPC临床分期、T分期及N分期的相关性。结果两位观察者对肿瘤病灶DKI各参数值测量的一致性很好,ICC>0.75。DKI参数MD值在临床分期中高级别组低于低级别组,MK值在临床分期中高级别组高于低级别组,MD值在T分期中高分期组低于低分期组,MK值在T分期中高分期组高于低分期组,MD值在N分期中高分期组低于低分期组,MK值在N分期中高分期组高于低分期组,差异有统计学意义(P<0.05),DKI参数FA、Da、Dr、FAK、Ka、Kr值在NPC临床分期、T分期及N分期差异均无统计学意义。结论DKI参数MD值、MK值与NPC的临床分期、T、N分期有关,临床分期高、T分期高、N分期高,MD值降低,MK值升高。
Objective To investigate the correlation between MRI diffusion kurtosis imaging(DKI)parameters and clinical stage of nasopharyngeal carcinoma(NPC).Methods 86 patients with pathologically proved NPC were scanned byDKI.DKI parameters included fractional anisotropy(FA),mean diffusivity(MD),axial diffusivity(Da),radial diffusivity(Dr),mean kurtosis(MK),axial kurtosis(Ka),radial kurtosis(Kr).FA of kurtosis(FAK)value.The consistency of the parameters of tumor focus DKI measured by the two observers was tested by intraclass correlation coefficient(ICC).To analyze the correlation between DKI parameters and NPC clinical stage,T stage and N stage.When the parameter values between the two groups were in accordance with the normal distribution,the differences of different groups were compared by two independent sample t⁃test.Results The values of DKI parameters of nasopharyngeal carcinoma lesions measured by the two observers were in good agreement(ICC>0.75).The MD values of DKI parameters in the high⁃grade group were lower than those in the low⁃grade group in the clinical stage,the MK value in the high⁃grade group was higher than the low⁃grade group in the clinical stage,the MD value in the T⁃stage high⁃grade group were lower than those in the low⁃grade group,and the MK value was In T stage,the high stage group was higher than the low stage group,the MD value in the N stage group were lower than those in the low stage group,and the MK value in the N stage high stage group was higher than the low stage group,and the difference was statistically significant(P<0.05).The values of DKI parameters FA,Da,Dr,FAK,Ka and Kr were not statistically significant in NPC clinical stage,T stage and N stage.Conclusion The MD value and MK value of DKI parameters were related to the clinical stage,T and N stage of NPC.The clinical stage,T stage and N stage were high,the MD value decreased and the MK value increased.
作者
吴英宁
黄莉娜
WU Yingning;HUANG Li′na(Department of Radiology,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,China)
出处
《实用医学杂志》
CAS
北大核心
2023年第13期1704-1708,共5页
The Journal of Practical Medicine
基金
广西医药卫生自筹经费计划课题(编号:20201596)。
关键词
磁共振成像
扩散峰度成像
鼻咽癌
临床分期
magnetic resonance imaging
diffusion kurtosis imaging
nasopharyngeal carcinoma
clinical stage
