摘要
肝移植已经成为终末期肝病的有效治疗手段,准确评估肝移植前后肝功能以及判断肝移植后复发是临床诊疗的重点。磁共振扩散加权成像、扩散峰度成像、血氧水平依赖成像、磁共振波谱、质子脂肪密度分数和磁共振弹性成像等功能磁共振技术及放射组学可以无创地从扩散、氧合、代谢、脂肪定量、肝脏硬度等方面评估移植肝,其临床价值在于早期发现肝功能受损、评估肝功能损伤程度及预测肝移植后复发进而帮助临床医生早期诊断疾病、为患者制订最优的诊疗方案和监测药物疗效,以提升患者生活质量。同时,其因新型无创并且能揭示肝移植病理改变将逐渐成为今后的研究热点。本文对多种功能磁共振成像及放射组学用于评估肝移植方面的研究现状做一综述,以期能为临床医生预测预后及制订治疗决策提供参考,并指导未来的研究方向。
Liver transplantation has become an effective treatment for end-stage liver disease.Accurate evaluation of liver function before and after liver transplantation and judgment of relapse after liver transplantation are the key points of clinical diagnosis and treatment.Functional magnetic resonance imaging(fMRI)techniques and radiomics such as magnetic resonance diffusion-weighted imaging,diffusion kurtosis imaging,blood oxygen level dependent imaging,magnetic resonance spectroscopy,proton fat density fraction and magnetic resonance elastography can noninvasionally evaluate the transplanted liver in terms of diffusion,oxygenation,metabolism,fat quantification,liver hardness,etc.To provide more information for the evaluation of liver function before and after liver transplantation and the judgment of relapse after liver transplantation.Its clinical value lies in early detection of liver function impairment,assessment of liver function injury degree and prediction of recurrence after liver transplantation,thus helping clinicians to diagnose disease early,formulate optimal diagnosis and treatment plan for patients and monitor drug efficacy,so as to improve the quality of life of patients.At the same time,it will gradually become a research hotspot in the future because it is new and non-invasive and can reveal pathological changes of liver transplantation.This article reviews the current status of fMRI and radiomics in evaluating liver transplantation,in order to provide reference for clinicians to predict prognosis and make treatment decisions,and to guide future research direction.
作者
陈浩远
张辉
王永芳
CHEN Haoyuan;ZHANG Hui;WANG Yongfang(College of Medical Imaging,Shanxi Medical University,Taiyuan 030001,China;Department of Radiology,First Hospital of Shanxi Medical University,Taiyuan 030001,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2023年第10期171-176,共6页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金项目(编号:82001807)。
关键词
肝移植
复发
急性排斥反应
磁共振成像
功能磁共振成像
放射组学
预后
liver transplantation
recurrence
acute cellular rejection
magnetic resonance imaging
functional magnetic resonance imaging
radiomics
prognosis
