摘要
目的探讨幽门螺杆菌相关性消化不良(HpD)与白介素-6(IL-6)、白介素-8(IL-8)关系。方法选取2020年5月至2021年10月苏州市相城人民医院消化内科门诊诊治的57例Hp阳性消化不良患者为研究对象。根除Hp前后检测IL-6、IL-8含量,根除治疗后随访6~12个月,根据消化道症状评分分为HpD组和功能性消化不良(FD)组。比较两组治疗前后IL-6、IL-8的表达水平,并绘制ROC曲线分析治疗前血清中IL-6、IL-8对HpD的早期诊断价值。结果随访12个月,50例患者根除成功,其中HpD组12例,FD组38例。HpD组根除Hp后1、3、6、12个月消化道症状评分低于治疗前,FD组仅治疗后1个月的消化道症状评分低于治疗前,差异有统计学意义(P<0.05)。治疗前两组的IL-6、IL-8比较,差异无统计学意义(P>0.05);治疗后FD组的IL-6和IL-8水平均高于HpD组,差异有统计学意义(P<0.05)。ROC曲线显示,治疗前血清IL-6水平预测HpD的AUC、敏感度、特异度、最佳截断点分别为0.711、75.0%、76.3%、89.95 pg/ml。血清IL-8水平预测HpD的AUC、敏感度、特异度、最佳截断点分别为0.724、87.21%、54.3%、281.25 pg/ml。结论Hp阳性的消化不良患者,血清中IL-6和IL-8可能作为HpD的早期预测指标之一。
Objective To investigate the relationship between Helicobacter pylori associated dyspepsia(HpD)and interleukin-6(IL-6)and interleukin-8(IL-8).Methods Fifty-seven patients with Hp-positive dyspepsia diagnosed and treated in the Department of Gastroenterology,Xiangcheng People's Hospital of Suzhou City from May 2020 to October 2021 were selected as the study objects.The levels of IL-6 and IL-8 were detected before and after the eradication of Hp,and the patients were followed up for 6-12 months after eradication.The patients were divided into HpD group and functional dyspepsia(FD)group according to the scores of digestive symptoms.The expression levels of IL-6 and IL-8 were compared between the two groups before treatment,and the ROC curve was drawn to analyze the value of serum IL-6 and IL-8 in the early diagnosis of HpD before treatment.Results After 12 months of follow-up,50 patients were successfully eradicated,including 12 in the HpD group and 38 in the FD group.The score of digestive tract symptom at 1,3,6 and 12 months after eradication of Hp in the HpD group was lower than that before treatment,and the score of digestive tract symptom at 1 month after treatment in the FD group was lower than that before treatment,the differences were statistically significant(P<0.05).There were no significant differences in IL-6 and IL-8 between the two groups before treatment(P>0.05).After treatment,the levels of IL-6 and IL-8 in FD group were higher than those in HpD group,and the differences were statistically significant(P<0.05).ROC curve showed that the AUC,sensitivity,specificity and optimal cut-off point of serum IL-6 before treatment were 0.711,75.0%,76.3%and 89.95,respectively.Serum IL-8 level predicted the AUC,sensitivity,specificity and optimal cut-off point of HpD were 0.724,87.21%,54.3%and 281.25,respectively.Conclusion IL-6 and IL-8 in serum of dyspepsia patients with positive Hp may be one of the early diagnostic indicators of HpD.
作者
乐安君
吴倩倩
张骥
秦志新
谈晓凯
马春涛
LE Anjun;WU Qianqian;ZHANG Ji;QIN Zhixin;TAN Xiaokai;MA Chuntao(Department of Gastroenterology,Xiangcheng People's Hospital of Suzhou City,Jiangsu Province,Suzhou215131,China)
出处
《中国当代医药》
CAS
2023年第20期58-61,共4页
China Modern Medicine
基金
江苏省苏州市科技发展计划项目(SYSD2019058)。
