摘要
目的 探讨根除幽门螺杆菌 (Helicobacterpylori ,Hp)对Hp阳性功能性消化不良 (functionaldyspepsia ,FD)症状的作用。方法 Hp阳性的FD12 0例随机分为 2个治疗组 :根除治疗组给予奥美拉唑 2 0mg、胶体次枸橼酸铋 2 40mg、克拉霉素 2 5 0mg和替硝唑 40 0mg四联治疗 ,均 2次 /d ;对照组给予法莫替丁 15 0mg 2次 /d和西沙必利 10mg 3次 /d ,疗程均为1周。治疗后随访 2年 ,在治疗后 1个月及随访 2年后行 1 3C 尿素呼气试验 ,并对症状进行评分。结果 治疗组Hp根除率为 91.7%。其中 ,Hp根除组 1个月末和 2年后的症状积分分别为 ( 1 4± 0 7) ,( 2 1± 0 9) ,显著低于对照组 ( 2 6± 0 9) ,( 3 8± 1 2 ) (P <0 0 1) ;Hp未根除组 1个月末症状积分为 ( 2 8± 1 1) ,与对照组无明显差异 (P >0 .0 5 )。
Objective To investigate the effects of Helicobacter pylori (Hp) eradication on the symptoms of Hp positive patients with functional dyspepsia (FD). Methods A total of 120 Hp positive FD patients proved by and 13 C UBT were randomly allocated into two groups: patients in treatment group received treatment of 20 mg omeprazole, 240 mg colloidal bismuth subcitrate, 250 mg clarithromycin, and 400 mg tinidazole twice daily, but those in the control group received treatment of 150 mg famotidine twice daily and 10 mg cisapride three times daily. The treatment course for both groups was one week. A follow up of 2 years was conducted. The status of Hp infection was determined by 13 C UBT at 1 month and 2 years after the eradication therapy. Symptom scores in the two groups were compared. Results The rate of Hp eradication was 91.7% in the treatment group. The symptom scores were (1 4±0 7) and (2 1±0 9) in eradication group and (2 6±0 9) and (3 8±1 2) in the control group at 1 month and 2 years after the eradication therapy ( P <0.01). The symptom score in patients with persistent Hp infection in the treatment group was (2 8±1 1) at 1 month after the eradication therapy and was not significantly different from that in the control group ( P >0 05). Conclusion The symptoms of Hp positive FD patients can be obviously improved after treatment by Hp eradication.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2004年第11期1013-1015,共3页
Journal of Third Military Medical University
关键词
根除幽门螺杆菌
功能性消化不良
随访研究
Helicobacter pylori eradication
functional dyspepsia
follow up study
