摘要
目的:探讨血小板内皮聚集受体1(platelet endothelial aggregation receptor 1,PEAR 1)基因多态性与脑梗死患者长期服用阿司匹林复发的相关性。方法:选取2022年3月—8月我院神经内科门诊及住院的长期服用阿司匹林的初发脑梗死患者297例,根据脑梗死复发情况分为复发组(145例)与无复发组(152例),采用单因素及多因素分析脑梗死复发的影响因素,并分析患者的PEAR 1基因型分布情况。结果:297例初发脑梗死患者中有145例患者复发,发生率为48.82%。单因素分析显示,脑梗死复发组与无复发组男性比例、高血压比例比较,差异无统计学意义(P>0.05);而两组年龄、吸烟、饮酒、糖尿病、PEAR 1基因变异占比比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,PEAR 1基因变异是脑梗死复发的影响因素(P<0.05)。145例复发患者PEAR 1检出GG、GA、AA三种基因型,其中野生型GG占32.6%,突变型GA占53.7%,AA占13.7%;复发组野生型GG频率低于无复发组(P<0.05),复发组纯合突变型AA的频率高于无复发组(P<0.05);两组GA频率比较,差异无统计学意义(P>0.05)。结论:PEAR 1基因变异与长期服用阿司匹林脑梗死卒中复发相关,PEAR 1基因纯合突变增加脑梗死复发的风险。
Objective:To investigate the correlation between platelet endothelial aggregation receptor 1(PEAR1)gene polymorphisms and long-term aspirin relapse in patients with cerebral infarction.Methods:A total of 297 patients with initial cerebral infarction who took aspirin in the outpatient department and inpatient department of Neurology of our hospital from March to August 2022 were selected.According to the recurrence of cerebral infarction,they were divided into the recurrence group(145 cases)and the non-recurrence group(152 cases).The influencing factors of cerebral infarction recurrence were analyzed by univariate and multivariate analysis,and the distribution of patients’PEAR1 genotype was analyzed.Results:Among 297 cases of initial cerebral infarction,145 cases recurred,with an incidence of 48.82%.Univariate analysis showed that there was no significant difference in the proportion of males and the proportion of hypertension between the cerebral infarction recurrence group and the non-recurrence group(P>0.05).There were statistically significant differences in age,smoking,drinking,diabetes and PEAR1 gene variation ratio between the two groups(P<0.05).Multivariate Logistic regression analysis showed that PEAR1 gene variation was an influential factor for cerebral infarction recurrence(P<0.05).Three genotypes,GG,GA and AA,were detected in 145 relapsed patients PEAR1,of which the wild type GG accounted for 32.6%,the mutant GA accounted for 53.7%and AA accounted for 13.7%.The frequency of wild type GG in recurrent group was lower than that in non-recurrent group(P<0.05),and the frequency of homozygous mutant AA in recurrent group was higher than that in non-recurrent group(P<0.05).There was no significant difference in GA frequency between the two groups(P>0.05).Conclusion:PEAR1 gene variation is associated with long-term aspirin use in cerebral infarction and stroke recurrence,and homozygous PEAR1 gene mutation increases the risk of cerebral infarction recurrence.
作者
石洪晨
李清
付文亭
SHI Hongchen;LI Qing;FU Wenting(Department of Neurology,Zaozhuang Central Hospital,Shandong Health Group,Zaozhuang 277500,Shandong,China)
出处
《中国药物滥用防治杂志》
CAS
2023年第6期987-989,994,共4页
Chinese Journal of Drug Abuse Prevention and Treatment
