摘要
目的探讨肉芽肿性小叶性乳腺炎(GLM)的MRI特征与临床病理的相关性,为未来通过MRI表现推测GLM的相关分子病理类型奠定基础。方法选取病理诊断为肉芽肿性小叶性乳腺炎的患者26例,根据MRI特征进行分类,采用多元有序Logistic、二元Logistic回归分析探讨MRI表现与临床病理的相关性,用spearmen相关分析探讨血清PRL水平与背景强化、导管扩张、脓肿形成的相关性。结果MRI表现为导管扩张的患者病理可见PRL-R表达水平升高;MRI表现为脓肿形成的患者在病理可见ER表达水平下降,且随着脓腔的不断扩大,ER的表达逐渐下降;血清PRL水平越高,则GLM患者背景强化越严重、脓肿形成越完全,呈正相关关系;脓肿形成与PRL-R的表达未见明显相关性,肿块内部强化类型及方式与ER、PRL-R的表达同样不具有相关性。结论血清PRL水平与GLM背景强化及脓肿形成、导管上皮PRL-R与GLM患者导管扩张、脓肿形成与导管上皮ER的破坏之间存在一定的相关性,通过分析相关性对GLM的本质进行更加深入的了解,以期为未来GLM的诊断提供参考。
Objective to investigate the correlation between MRI features and clinicopathology of granulomatous lobular mastitis,and to lay a foundation for speculating the related pathological types of GLM from MRI findings in the future.Methods 26 patients with granulomatous lobular mastitis were selected and classified according to the characteristics of MRI.Multivariate ordered Logistic and binary Logistic regression analysis were used to explore the correlation between MRI manifestations and clinical pathology.Spearmen correlation analysis was used to explore the correlation between serum PRL levels and background enhancement,ductal dilatation and abscess formation.Results The expression of PRL-R increased pathologically in patients with ductal dilatation in MRI,and the expression of ER decreased in patients with abscess in MRI,and decreased gradually with the enlargement of the abscess.The higher the serum PRL level,the more serious the background enhancement and the more complete the formation of abscess in GLM patients,showing a positive correlation.There was no significant correlation between the formation of abscess and the expression of PRL-R,and there was no correlation between the type and mode of enhancement in the mass and the expression of ER and PRL-R.Conclusion There is a certain correlation between plasma PRL level and GLM background enhancement and abscess formation,ductal epithelial PRL-R and GLM patients with ductal dilatation,abscess formation and catheter epithelial ER destruction.Through these correlation studies,we can have a deeper understanding of the nature of GLM,in order to bring more clear guiding significance for the treatment of GLM in the future.
作者
杜楠楠
冯佳梅
吴雪卿
DU Nannan;FENG Jiamei;WU Xueqing(Department of Breast Diseases,Shuguang Hospital of Shanghai University of TCM,Shanghai 200021,China)
出处
《医学影像学杂志》
2023年第6期1003-1007,共5页
Journal of Medical Imaging
基金
上海市卫生健康委员会科研课题项目(编号:202040254)。
关键词
肉芽肿性小叶性乳腺炎
磁共振成像
临床病理
相关性
Granulomatous lobular mastitis
Magnetic resonance imaging
Clinicopathology
Correlation
