摘要
头颈部肿瘤颈部放疗后,会引起甲状腺功能减退(hypothyroidism,HT),5年发生率于20%~60%之间。本文综述了放疗剂量-体积参数、年龄、放射技术、性别等因素与放射治疗引起的甲状腺功能减退(radiation-induced hypothyroidism,RIHT)的关系,以及产生的机制。甲状腺的剂量-体积阈值相关研究很多,但结论不一,不能明确定义。但共识是较高的甲状腺剂量和较小的甲状腺体积会增加RIHT的发生率,年龄、放射技术、性别会对RIHT的发生有影响。需大量前瞻性大样本进一步研究来开发更多的正常组织并发症概率(normal tissue complication probability,NTCP)模型及探讨下丘脑-垂体轴和RIHT之间的关系。
After radiotherapy for head and neck tumors,it will cause hypothyroidism(HT),and the incidence rate in 5 years is between 20%to 60%.This paper reviews the relationship between RIHT and radiation dose-volume parameters,age,radiation technology,gender and generative mechanism.There are many studies,but the conclusions are different,then the dose-volume threshold cannot be defined clearly.The consensus is that higher thyroid dose and smaller thyroid volume will increase the incidence of RIHT,the age,radiation technology and gender will have an impact on RIHT.A large number of prospective large samples are needed for further research to develop more normal tissue complication probability(NTCP)models and explore the relationship between hypothalamic-pituitary axis and RIHT.
作者
赵利宏
郝春成
ZHAO Lihong;HAO Chuncheng(Heilongjiang Cancer Hospital,Heilongjiang Harbin 150000,China)
出处
《现代肿瘤医学》
CAS
北大核心
2023年第14期2719-2722,共4页
Journal of Modern Oncology
