摘要
目的:探讨血清相关细胞因子水平变化与围绝经期功血患者月经失血图(PBAC)评分的相关性及联合诊断的价值。方法:选取我院2020年4月-2022年3月收治的87例围绝经期功血患者为观察组,同期87例健康体检妇女为对照组。比较两组入院时性激素[雌二醇(E_(2))、卵泡刺激素(FSH)、黄体生成素(LH)]水平、子宫内膜厚度及PBAC评分、血清一氧化氮(NO)、血管内皮生成因子(VEGF)、碱性成纤维细胞生长因子(bFGF)水平,分析入院时血清NO、VEGF、bFGF水平与性激素水平、子宫内膜厚度及PBAC评分的相关性,及入院时血清NO、VEGF、bFGF水平联合检测对围绝经期功血的诊断价值,各指标对围绝经期功血的危险度。结果:与对照组相比,入院时观察组E_(2)、FSH、LH、NO水平及PBAC评分较高,VEGF、bFGF水平较低,子宫内膜厚度较厚较高(P<0.05);入院时血清NO水平与E_(2)、FSH、LH、子宫内膜厚度、PBAC评分呈正相关(P<0.05),入院时血清VEGF、bFGF水平与E_(2)、FSH、LH、子宫内膜厚度、PBAC评分呈负相关(P<0.05);入院时血清NO、VEGF、bFGF水平联合诊断围绝经期功血的AUC为0.843,优于各指标单一诊断,且高水平患者发生围绝经期功血危险度分别是低水平的1.914、0.644、0.419倍。结论:血清NO、VEGF、bFGF水平与PBAC评分紧密相关,联合检测对临床预测围绝经期功血具有一定价值。
Objective:To investigate the correlation between the changes of serum related cytokines and the menstrual blood loss chart(PBAC)score of perimenopausal dysfunctional uterine bleeding patients and the value of combined diagnosis.Methods:87 patients with perimenopausal dysfunctional uterine bleeding admitted to our hospital from April 2020 to March 2022 were selected as the observation group,and 87 normal women who underwent physical examination were selected as the control group.To compare the levels of sex hormones[estradiol(E_(2)),follicle stimulating hormone(FSH),luteinizing hormone(LH)],endometrial thickness and PBAC score,serum nitric oxide(NO),vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF)at admission between the two groups,and analyze the correlation between the levels of serum NO,VEGF,bFGF at admission and the levels of sex hormones,endometrial thickness and PBAC score,as well as the level of serum NO The diagnostic value of combined detection of VEGF and bFGF levels for perimenopausal dysfunctional uterine bleeding,and the risk of each index for perimenopausal dysfunctional uterine bleeding.Results:Compared with the control group,the levels of E_(2),FSH,LH,VEGF,bFGF and PBAC in the observation group at admission were lower,the endometrial thickness was thicker and the level of NO was higher(P<0.05);The serum NO level at admission was negatively correlated with E_(2),FSH,LH,PBAC scores,and positively correlated with endometrial thickness(P<0.05).The serum VEGF and bFGF levels at admission were positively correlated with E_(2)FSH,LH,PBAC scores,and negatively correlated with endometrial thickness(P<0.05);The AUC of combined diagnosis of perimenopausal dysfunctional uterine bleeding with serum NO,VEGF and bFGF levels at admission was 0.830,which was superior to the single diagnosis of each index.The risk of perimenopausal dysfunctional uterine bleeding in patients with high levels was 1.914,0.659 and 0.421 times higher than that in patients with low levels.Conclusion:The levels
作者
李建敏
刘玉凤
杜晨旭
LI Jianmin;LIU Yufeng;DU Chenxu(Laboratory Department of Zhengzhou Central Hospital Affiliated to Zhengzhou University,Henan Zhengzhou 450000)
出处
《医学检验与临床》
2023年第5期18-21,共4页
Medical Laboratory Science and Clinics
关键词
围绝经期功血
诊断
PBAC评分
NO
VEGF
Perimenopausal dysfunctional uterine bleeding,Diagnosis
PBAC score
NO
VEGF
