摘要
目的:旨在评价SSc患者外周血中辅助性T细胞(Th)17比例及其与疾病的相关性。方法:检索中文数据库中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM),万方数据库和维普数据库,英文数据库PubMed、EMBASE、Web of Science、Cochrane Library和Science Direct,收集有关SSc患者外周血Th17细胞含量的病例-对照研究,检索时限为建库起至2021年2月25日,Meta分析采用Stata 12.0软件,I^(2)与Egger检验用于评估研究间异质性与发表偏倚。结果:共26个病例-对照研究纳入分析,包括1160例SSc患者,778名健康对照组。总体而言,SSc患者中Th17细胞的比例高于健康对照组[标准化均数差(95%CI)=1.85(1.33,2.38),P<0.001]。其中,IL-17+Th17细胞在SSc患者外周血中的比例更高[标准化均数差(95%CI)=1.88(1.28,2.48),P<0.001]。活动期SSc患者外周血Th17细胞比例显著高于缓解期[标准化均数差(95%CI)=1.92(1.12,2.71),P<0.001]。治疗后的SSc患者Th17细胞比例显著低于治疗前[标准化均数差(95%CI)=-0.74(-1.05,-0.42),P=0.029]。结论:Th17细胞在SSc患者的外周血中明显增多,且与疾病活动性相关,DMARDs药物可通过下调SSc患者Th17水平发挥治疗作用。
Objective To clarify peripheral Th17 level in SSc patients and its correlation with disease.Methods Chinese databases CNKI,CBM,Wanfang and VIP,and English databases PubMed,EMBASE,Web of Science,Cochrane Library and Science Direct were searched to collect a case-control study on the content of Th17 cells in peripheral blood of patients with SSc.The papers published when the database was first developed in 25 February 2021.Meta-analysis was conducted using Stata 12.0 software,and I^(2) and Egger tests were used to evaluate the heterogeneity and publication bias between studies.Results A total of 26 case-controls were included in the study,including 1160 patients with SSc and 778 healthy controls.Overall,the percentage of Th17 cells in SSc patients was higher than in healthy controls[SMD(95%CI)=1.85(1.33,2.38),P<0.001],which was most significant in IL-17+Th17 concentration[SMD(95%CI)=1.88(1.28,2.48),P<0.001].As for disease activity,the proportion of Th17 cells in active SSc patients was much higher than those of patients in remission[SMD(95%CI)=1.92(1.12,2.71),P<0.001].SSc patients had a reduced Th17 level after receiving DMARDs treatment[SMD(95%CI)=-0.74(-1.05,-0.42),P=0.029].Conclusion The number of Th17 cells increase significantly in the peripheral blood of patients with SSc,and is related to disease activity.DMARDs can be used to treat this disease by downregulating Th17 levels.
作者
李彦蓉
宋蔚
李芸
樊梦颖
王杏如
李嘉颖
张升校
王彩虹
Li Yanrong;Song Wei;Li Yun;Fan Mengying;Wang Xingru;Li Jiaying;Zhang Shengxiao;Wang Caihong(The Second Clinical Medical College of Shanxi Medical University,Taiyuan 030001,China;The First Clinical Medical College of Shanxi Medical University,Taiyuan 030001,China;College of Anesthesiology,Shanxi Medical University,Taiyuan 030001,China;Department of Pediatric Medicine,Shanxi Medical University,Taiyuan 030001,China;Department of Rheumatology and Immunology,The Second Hospital of Shanxi Medical University,Taiyuan 030001,China)
出处
《中华风湿病学杂志》
CAS
CSCD
北大核心
2023年第4期236-242,共7页
Chinese Journal of Rheumatology
基金
国家自然科学基金青年基金(82001740)。
