摘要
目的:从干预“内痈”角度观察解毒消痈方治疗急性冠脉综合征(痰瘀互结证)的临床疗效。方法:96例急性冠脉综合征患者随机平均分为3组。西药+中药组:西医常规治疗+中医诊疗方案;试验组:西医常规治疗+中医诊疗方案+解毒消痈方;西药组:西医常规治疗。治疗1个疗程后,比较3组患者临床疗效、中医症状评分、心绞痛发作情况、心电图、血清炎症因子[肿瘤坏死因子-α(tumour necrosis factor-α,TNF-α)、白细胞介素-1(interleukin-1,IL-1)、基质金属蛋白酶-9(matrix metalloprotein-9,MMP-9)、可溶性白细胞分化抗原40配体(soluble CD40 ligand,SCD40L)]水平。结果:(1)治疗后,3组患者临床疗效经LSD法两两比较,试验组优于西药组,差异有统计学意义(P<0.01);试验组优于西药+中药组,差异有统计学意义(P<0.05);西药+中药组优于西药组,差异有统计学意义(P<0.05)。(2)治疗后,3组患者在降低心绞痛发作频率、心绞痛发作持续时间方面均显著改善。经LSD法两两比较:试验组在降低心绞痛发作频率和降低心绞痛持续时间方面优于西药+中药组,差异有统计学意义(P<0.01);试验组优于西药组,差异有统计学意义(P<0.01);西药+中药组优于西药组,差异有统计学意义(P<0.01)。(3)治疗后,3组患者中医症状总积分均显著降低(P<0.01)。经LSD法两两比较:试验组中医症状总积分低于西药+中药组及西药组,差异均有统计学意义(P<0.01);西药+中药组中医症状总积分低于西药组,差异均有统计学意义(P<0.05)。(4)心电图疗效经LSD法两两比较:试验组疗效优于西药+中药组及西药组(P<0.01);西药+中药组疗效优于西药组(P<0.05)。(5)治疗后,3组患者TNF-α、IL-1、MMP-9、SCD40L水平均显著降低,差异均有统计学意义(P<0.01);经LSD法两两比较:试验组以上指标水平显著低于同期西药+中药组、西药组(P<0.01);西药+中药组TNF-α、IL-1、MMP-9水平显著低于西药组(P<0.01)。
Objective:To observe the clinical efficacy of Jiedu Xiaoyong Formula in treating acute coronary syndrome(phlegm stasis syndrome)from the perspective of intervening in"internal carbuncle".Method:96 patients with acute coronary syndrome were randomly divided into 3 groups:Western medicine+traditional Chinese medicine group:Western medicine conventional treatment+traditional Chinese medicine diagnosis and treatment plan;Experimental group:conventional Western medicine treatment+traditional Chinese medicine diagnosis and treatment plan+Jiedu Xiaoyong Formula;Western medicine group:routine Western medicine treatment.After one course of treatment,compare the clinical efficacy,traditional Chinese medicine symptom score,angina attack status,electrocardiogram,and levels of serum inflammatory factors,including tumour necrosis factor-α(TNF-α),Interleukin-1(IL-1),matrix metalloproteinase-9(MMP-9),soluble CD40 ligand(SCD40L)between the two groups.Results:(1)After treatment,the clinical efficacy of the three groups of patients was compared by LSD method,and the experimental group was superior to the Western medicine group,with a statistically significant difference(P<0.01);The experimental group was superior to the Western medicine+Chinese medicine group,with a statistically significant difference(P<0.05);The Western medicine+traditional Chinese medicine group was superior to the Western medicine group,with a statistically significant difference(P<0.05).(2)After treatment,the three groups of patients showed significant improvement in reducing the frequency and duration of angina attacks.Through pairwise comparison using LSD method,the experimental group showed a statistically significant difference in reducing the frequency and duration of angina pectoris compared to the Western medicine+Chinese medicine group(P<0.01);The experimental group was superior to the Western medicine group,with a statistically significant difference(P<0.01);The Western medicine+traditional Chinese medicine group was superior to the Western medicine
作者
石锐
于克英
田腾辉
陈浩
薛雯
邓悦
SHI Rui;YU Keying;TIAN Tenghui;CHEN Hao;XUE Wen;DENG Yue(Changchun University of Traditional Chinese Medicine/Cardiovascular Disease Branch of National Clinical Medical Research Center for Traditional Chinese Medicine,Changchun Jilin China 130021)
出处
《中医学报》
CAS
2023年第6期1285-1290,共6页
Acta Chinese Medicine
基金
吉林省科技发展计划资助项目(20190303166SF)
吉林省教育厅科学技术研究项目(JJKH20210985KJ)
吉林省中医心血管病临床医学研究中心资助项目(YDZJ202202CXJD046)
全国名老中医药专家传承工作室项目。
关键词
急性冠脉综合征
解毒消痈方
痰瘀互结证
acute coronary syndrome
Jiedu Xiaoyong Formula
Syndrome of mutual accumulation of phlegm and blood stasis
