摘要
脑部缺氧经常带来不可逆的中枢神经系统损伤,严重危害着人类健康,对缺氧相关脑损伤机制的深入探索具有重要意义。铁死亡作为一种程序性细胞死亡,主要表现为铁依赖性脂质过氧化物过量积累导致的细胞死亡,与谷胱甘肽代谢、脂质过氧化和铁代谢异常相关,参与多种疾病的发生和发展。研究发现铁死亡在缺氧相关脑损伤中发挥重要作用。本文总结了铁死亡的发生机制,并阐述了其在脑缺血再灌注损伤、新生儿缺氧缺血性脑损伤、阻塞性睡眠呼吸暂停所致脑损伤及高原低氧脑损伤中的研究进展。
Cerebral hypoxia often brings irreversible damage to the central nervous system,which seriously endangers human health.It is of great significance to further explore the mechanism of hypoxia-associated brain injury.As a programmed cell death,ferroptosis mainly manifests as cell death caused by excessive accumulation of iron-dependent lipid peroxides.It is associated with abnormal glutathione metabolism,lipid peroxidation and iron metabolism,and is involved in the occurrence and development of various diseases.Studies have found that ferroptosis plays an important role in hypoxia-associated brain injury.This review summarizes the mechanism of ferroptosis,and describes its research progress in cerebral ischemia reperfusion injury,neonatal hypoxic-ischemic brain damage,obstructive sleep apnea-induced brain injury and high-altitude hypoxic brain injury.
作者
常熙雯
赵安鹏
姚菀腾
李文斌
王荣
CHANG Xi-Wen;ZHAO An-Peng;YAO Wan-Teng;LI Wen-Bin;WANG Rong(Department of Pharmacy,The 940th Hospital of PLA Joint Logistics Support Force,Lanzhou 730050,China;School of Pharmacy,Lanzhou University,Lanzhou 730000,China)
出处
《生理学报》
CAS
CSCD
北大核心
2023年第2期255-268,共14页
Acta Physiologica Sinica
基金
supported by the Science Foundation for Young Scholars of Gansu Province,China(No.20JR10RA014)
the National Natural Science Foundation of China(No.82173738)。
