摘要
FoxO1转录因子属于Fox家族成员,主要参与细胞凋亡、应激、DNA损伤/修复、肿瘤发生、血管生成和糖代谢等生命过程.PI-3K和Akt信号通路可磷酸化FoxO1,使其由胞核转运至胞质,导致转录活性灭活,从而抑制FoxO1所调控的下游基因表达.FoxO1的乙酰化可削弱FoxO1结合同源DNA序列的能力,同时加强FoxO1的磷酸化,进一步降低其转录活性.正是由于FoxO1本身的翻译后修饰可调节FoxO1的功能,使得其在肿瘤发生、免疫反应、细胞周期、分化、代谢、应激和凋亡中都起着重要的作用.本文对FoxO1及其翻译后修饰的生物学意义进行综述.
As a member of the Fox family,FoxO1 transcription factor is involved in the regulation of apoptosis,oxidative stress,DNA damage repair,cancer development,angiogenesis and glucose metabolism.The phosphatidylinositol 3-kinase（PI3K） in the Akt pathway phosphorylates FoxO1 and mobilizes FoxOl from the nuclei to the cytoplasm,leading to inactivation of FoxO1 and its impact on the downstream targets.Acetylation of FoxO1 attenuates its binding to the target DNA and enhances its phosphorylation,thereby decreases the transcription activities of FoxO1.This review focuses on the FoxO1 posttranslational modifications and their roles in the transcriptional regulation.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2010年第3期203-208,共6页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家大学生创新性实验计划(中山大学2008-34)
中山大学逸仙创新人才培养计划(2009)~~
关键词
FOXO1
转录因子
磷酸化
乙酰化
FoxO1
transcription factor
phosphorylation
acetylation
