摘要
为开发功能性含锌和含铜纤维及医用敷料在伤口护理中的应用,介绍了锌离子和铜离子的生物活性及其在伤口愈合过程中的作用,总结了国内外市场上各种含锌和含铜医用敷料及其制备方法,重点介绍了含锌和含铜的海藻酸盐纤维、壳聚糖纤维,以及通过静电纺丝、高分子材料复合加工、纳米技术等先进工艺制备的各种含锌和含铜医用敷料及其释放锌离子和铜离子的性能。指出锌离子和铜离子具有优良的抗菌及促进伤口愈合的功效,含锌和含铜医用敷料通过释放锌离子和铜离子,对创面常见的各种细菌有很强的抑菌作用,在烧伤、下肢溃疡、糖尿病足溃疡、褥疮等伤口护理中有重要的应用价值。
Significance In order to develop the applications of functional zinc and copper containing fibers and wound dressings in the management of chronic wounds,this paper introduced the bioactivities of zinc and copper ions and their roles in the wound healing process,and summarized the types and production methods of zinc and copper containing wound dressings in the domestic and international market,in particular zinc and copper containing alginate fibers,chitosan fibers,and the various types of zinc and copper containing wound dressings and their ion releasing properties obtained by electrospinning,polymeric composites,nano technologies and other advanced processing methods.Both zinc and copper ions possess antimicrobial efficacy and are known to be able to promote wound healing.The incorporation of these two metal ions by the techniques reviewed in this paper can help manufacturers and medical practitioners in the wound management industry to fully utilize the novel health benefitting properties of zinc and copper ions.Progress Both zinc and copper ions have been used in the wound management industry for a long time by many forms of applications.Recent progresses are mainly focused in the sustainable release of zinc and copper ions by combining these two ions with alginate,chitosan and other novel substrate materials,and also by the use of nanoparticles of zinc oxide and copper oxide.The incorporation of zinc ions into alginate fibers and the subsequent release of zinc ions when in contact with aqueous solutions containing different levels of protein were summarized.The composition and properties of many types of zinc containing wound dressings reported in the documents were summarized.Regarding copper containing wound dressings,important progress has been made by incorporating copper oxide into fibers by blending and the subsequent extrusion to form copper containing fibers.In addition,copper ions can be absorbed into various types of alginate fibers that can be released when these fibers are in contact with aqueou
作者
秦益民
QIN Yimin(College of Material and Textile Engineering,Jiaxing University,Jiaxing,Zhejiang 314001,China;State Key Laboratory of Bioactive Seaweed Substances,Qingdao,Shandong 266400,China)
出处
《纺织学报》
EI
CAS
CSCD
北大核心
2023年第5期213-219,共7页
Journal of Textile Research
基金
国家重点研发计划项目(2018YFC1105600)。
关键词
锌离子
铜离子
功能纤维
医用敷料
医用纺织材料
创面护理
zinc ion
copper ion
functional fiber
wound dressing
medical textile material
wound management
