摘要
目的:探讨中医药治疗慢性阻塞性肺疾病(COPD)的用药规律,以期为临床用药提供参考。方法:检索中国知网(CNKI)、万方数据(WANFANG DATA)、维普中文科技期刊数据库(VIP),筛选中医药治疗COPD的文献,建立方剂数据库,采用IBM SPSS Modeler 18.0软件进行关联规则分析,采用Cytoscape 3.7.2软件构建核心药物网络图,采用SPSS Statistics 21.0软件进行系统聚类分析及因子分析。结果:共纳入处方331首,涉及药物231味,总用药频次3606次。COPD证型以痰热壅肺证、肺肾两虚证、痰浊壅肺证、肺脾气虚证、痰瘀阻肺证等为主。症状以咳嗽、喘息、咳痰、胸闷、呼吸困难、气短、发热、乏力等为主。高频药物有茯苓、苦杏仁、甘草、法半夏等。药物四气以温热性为主,药味以甘、苦、辛味为主,多归肺、肝、脾、胃经。以补虚药应用最多,其次是化痰止咳平喘药等。关联规则分析发现关联强度较高的规则有20条,系统聚类分析得出4个新处方,因子分析可提取公因子9个。结论:中医药治疗COPD以化痰止咳、补虚、利水、理气、活血等为基本治则进行组方配伍。
Objective:To investigate the medication rule in traditional Chinese medicine(TCM)treatment of chronic obstructive pulmonary disease(COPD),and to provide a reference for clinical medication.Methods:CNKI,WANFANG DATA,and VIP were searched for articles on TCM treatment of COPD,and a database was established for related prescriptions.IBM SPSS Modeler 18.0 software was used for association rule analysis,Cytoscape 3.7.2 software was used to construct a core drug network,and SPSS Statistics 21.0 software was used for hierarchical cluster analysis and factor analysis.Results:A total of 331 prescriptions were included,involving 231 TCM drugs,with a total frequency of 3606.The main syndrome types of COPD included syndrome of phlegm-heat obstructing the lung,syndrome of lung-kidney deficiency,syndrome of turbid phlegm obstructing the lung,syndrome of lung-spleen Qi deficiency,and syndrome of phlegm and blood stasis obstructing the lung,and the main symptoms included cough,wheezing,expectoration,chest distress,dyspnea,short breath,pyrexia,and weakness.High-frequency drugs included Poria cocos,Semen Armeniacae Amarum,Radix Glycyrrhizae,and Rhizoma Pinelliae Praeparatum.Most TCM drugs were warm or hot in nature and had a sweet,bitter or pungent taste,and they mainly entered the lung,liver,spleen,and stomach meridians.Deficiency-tonifying herbs were the most frequently used drugs,followed by phlegm-eliminating,cough-relieving,and asthma-relieving drugs.The association rule analysis showed 20 rules with a relatively high strength of association,the hierarchical cluster analysis obtained 4 new prescriptions,and the factor analysis obtained 9 common factors.Conclusion:In TCM treatment of COPD,compatibility of prescriptions is determined based on the principles of removing phlegm and relieving cough,tonifying deficiency,promoting diuresis,regulating Qi,and activating blood circulation.
作者
杨萍
瞿继兰
YANG Ping;QU Jilan(Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,Gansu,China;Gansu Provincial People’s Hospital,Lanzhou 730013,Gansu,China)
出处
《湖南中医杂志》
2023年第4期19-24,共6页
Hunan Journal of Traditional Chinese Medicine
关键词
慢性阻塞性肺疾病
证型
症状
用药规律
chronic obstructive pulmonary disease
syndrome type
symptom
medication rule
