摘要
目的:探究人乳头状瘤病毒(HPV)感染并阴道上皮内瘤变(VAIN)患者采用干扰素配合CO_(2)激光治疗的应用效果。方法:选取常德市第一人民医院2017年7月至2019年7月收治的194例HPV感染并VAIN患者,依据随机数字表法分组为A组(64例,采用CO_(2)激光治疗),B组(64例,采用CO_(2)激光配合保妇康栓治疗),C组(66例,采用CO_(2)激光配合干扰素治疗),比较各组患者的疗效。结果:治疗后C组患者的阴道出血量、阴道排液量低于A组、B组,且阴道出血时间、阴道排液时间少于A组、B组,差异具有统计学意义(P<0.05)。治疗后C组患者不同时间段的病变逆转率均高于A组、B组,差异具有统计学意义(P<0.05)。治疗后2年各组患者恶化率比较,差异无统计学意义(P>0.05)。C组患者的不同时段病变复发率均低于A组、B组,且不同时段HPV转阴率均高于A组、B组,差异具有统计学意义(P<0.05)。结论:干扰素配合CO_(2)激光治疗可显著减轻本研究患者术后阴道出血量,且治疗后不易复发。
Objective To investigate the effect of interferon combined with CO_(2)laser in the treatment of human papilloma virus(HPV)infection and vaginal intraepithelial neoplasa(VAIN).Methods A total of 194 patients with HPV infection and VAIN treated in the First People's Hospital of Changde from July 2017 to July 2019 were selected and divided into group A(64 cases,treated with CO_(2)laser),group B(64 cases,treated with CO_(2)laser combined with Baofukang Shuan),and group C(66 cases,treated with CO_(2)laser combined with interferon)according to random number table method,the efficacy of each group was compared.Results After treatment,the amount of vaginal bleeding and vaginal drainage in group C was lower than that in group A and group B,and the time of vaginal bleeding and vaginal drainage was lower than that in group A and group B,the differences were statistically significant(P<0.05).After treatment,the reversal rate of lesions in group C was higher than that in group A and group B at different time periods,and the differences were statistically significant(P<0.05).There was no significant difference in the rate of deterioration 2 years after treatment among all groups(P>0.05).The recurrence rate of lesions in group C was lower than that in group A and Group B at different periods,and the HPV negative conversion rate was higher than that in group A and group B at different periods,the differences were statistically significant(P<0.05).Conclusion Interferon combined with CO_(2)laser therapy can significantly reduce postoperative vaginal bleeding in the patients in this study,and it is not easy to relapse after treatment.
作者
谢家敏
张瑛
柳亭亭
邱浩
唐欣
王黎
XIE Jia-min;ZHANG Ying;LIU Ting-ting;QIU Hao;TANG Xin;WANG Li(The First People's Hospital of Changde,Hunan Changde 415000)
出处
《深圳中西医结合杂志》
2023年第6期8-10,共3页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金
常德市科技局指导性项目(2020ZD93)
常德市科技局一般项目(常科函202075号)。
